Trajectories of brain network development from birth to adolescence mediate the relationship between socioeconomic status and psychopathology development
Active Project Grant Awarded Last action
- Award ID
- F31MH144861
- Recipient
-
University Of North Carolina At Chapel Hill UEI D3LHU66KBLD5 Part of University Of North Carolina System Office
- Awarding agency
-
National Institute of Mental Health
National Institutes of Health, Department of Health and Human Services
- Obligated
- $83,450
Award facts
- Assistance listing
- 93.242 Mental Health Research Grants
- Completion date 0% complete
- Originally
- Place of performance
- Chapel Hill, NC 27599, USA
Award details come from USAspending.gov.
Description
- Abstract
- Low socioeconomic status (SES) is consistently associated with increased rates of psychopathology. Current literature suggests that childhood SES gives rise to psychopathology through its impact on brain development during times of increased brain plasticity. Although brain plasticity peaks in early childhood, rates of psychopathology peak in adolescence. To understand how SES in early childhood increases risk for adolescent psychopathology, IT is critical to understand not only how SES impacts early brain development, but how IT may cause long-term shifts in neurodevelopmental trajectories throughout childhood and adolescence. There have been inconsistent findings regarding structure and function of individual brain regions mediate the relationship between SES and psychopathology. Instead of measuring individual brain regions, recent work investigating how groups of brain regions function together as a network have found associations between aberrant functioning of specific brain networks and transdiagnostic psychopathology risk, therefore studying networks may be particularly promising for resolving the inconsistencies in the literature. Thus, this proposal will leverage insights from network neuroscience to provide a novel perspective into how SES impacts trajectories of brain network development and psychopathology across both early life and adolescence in the same individuals. The proposed study will leverage the university of north carolina at chapel hill's (UNC-CH) early brain development study (EBDS). This unique longitudinal dataset has 10 timepoints of fmri data from birth to 16 years old, and measures psychopathology symptoms starting in early childhood. Crucially, 40% of participants are at high risk for psychopathology due to premature birth or maternal psychiatric diagnosis. Thus, this dataset is ideally suited for a longitudinal study examining neurodevelopment and outcomes of psychopathology. To accomplish this goal, this project will 1) assess how SES impacts the developmental trajectories of externalizing and internalizing psychopathology from early childhood through adolescence, 2) analyze the developmental trajectories of brain network development from infancy to adolescence across SES, and 3) understand how brain network development mediates the relationship between SES and psychopathology outcomes. Training aims include developing a theoretical understanding of SES, neurodevelopment, and psychopathology, as well as advanced training in methods of network neuroscience and longitudinal modeling. The results of these aims will advance knowledge of how SES impacts neurodevelopment, and could identify periods of increased plasticity to be targeted in future prevention and intervention strategies. The combination of incredible resources available at UNC-CH, as well as mentors around the world specializing in these areas of research, will prepare the trainee to use this research project and training plan to build a productive career as an independent researcher studying how SES impacts neurodevelopment, and leads to risk for psychopathology.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Original award | $41,725 |
Quick answers
Who received award F31MH144861?
F31MH144861 was awarded to University Of North Carolina At Chapel Hill by National Institute of Mental Health (National Institutes of Health) on December 1, 2026.
How much is award F31MH144861 worth?
$83,450 has been obligated on F31MH144861.
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