Blurring of the airway-alveolar boundary: dissecting the mechanism underlying bronchiolization
Active Project Grant Awarded Last action
- Award ID
- F31HL186821
- Recipient
-
University Of California, San Diego UEI UYTTZT6G9DT1
- Awarding agency
-
National Heart Lung and Blood Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $86,880
Award facts
- Assistance listing
- 93.837 Cardiovascular Diseases Research
- Completion date 0% complete
- Originally
- Place of performance
- La Jolla, CA 92093, USA
Award details come from USAspending.gov.
Description
- Abstract
- Bronchiolization of alveoli - replacement of gas-exchange epithelium by airway-like cells - is the project's key focus because IT cripples pulmonary function in pulmonary fibrosis. The long-term goal is to identify and pharmacologically target stress- and glycosylation-driven pathways that destabilize alveolar identity, thereby advancing therapies that align with NIH's mission to reduce morbidity from chronic lung disease. Guided by three specific aims, the applicant will (1) pinpoint the integrated-stress-response kinase triggering ATF4 activation, (2) determine whether ISR-ATF4 signaling is necessary and sufficient for bronchiolization, and (3) establish how ATF4-induced FUT1-mediated Α1,2-fucosylation suppresses BMP4 signaling and shifts airway-alveolar cell competition. The research design combines phospho-proteomics, genetic and small-molecule kinase blockade, conditional gene deletion, lineage-traced organoids, single-cell RNA-sequencing, quantitative histology, and lung-function testing to deliver mechanistic clarity and druggable nodes. The fellowship training plan integrates advanced coursework in single-cell genomics, glycobiology, and organoid engineering with BI-weekly mentor meetings, grant-writing workshops, and lungmap consortium bootcamps to cultivate technical breadth, analytical rigor, and leadership. The training environment - the UC SAN diego lung center, epigenomics and imaging cores, glycobiology facility, and multidisciplinary fibrosis network - provides state-of-the-art resources, expert consultation, and a collaborative culture that will accelerate the candidate's development into an independent investigator.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $43,440 | |
| Amendment | $43,440 | |
| Original award | $0 |
Quick answers
Who received award F31HL186821?
F31HL186821 was awarded to University Of California, San Diego by National Heart Lung and Blood Institute (National Institutes of Health) on December 15, 2026.
How much is award F31HL186821 worth?
$86,880 has been obligated on F31HL186821.
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