The role of actin polymerization in plasma membrane scission during clic/geec endocytosis

Active Project Grant Awarded Last action

Award ID
F31HL186676
Recipient
Awarding agency
Obligated
$49,637

Award facts

Assistance listing
93.837 Cardiovascular Diseases Research
Completion date 0% complete
Place of performance
Seattle, WA 98195, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Cell membranes act as protective barriers that must be constantly maintained through a process called endocytosis, where cells absorb materials from their surroundings and recycle membrane-bound proteins. One type of endocytosis, called clic/geec endocytosis, is particularly important because IT can completely refresh a cell's entire membrane in just 15-20 minutes while taking in large amounts of fluid. This process is especially critical in lung cells. When patients develop acute lung injury or respiratory distress syndrome, their lung cells cannot properly clear fluid buildup or repair damage. Clic/geec endocytosis helps maintain healthy membrane function and cell structure, making IT a potentially critical pathway in normal lung cell behavior. The process works by forming tube-shaped structures that pinch off from the cell membrane, requiring a protein network called actin to function properly. However, scientists still DON't understand exactly how these tubules are cut away from the membrane - a key missing piece of knowledge. When clic/geec endocytosis doesn't work correctly, cells struggle to respond to mechanical stress and seem to have different migration behaviors. In model systems, defects in clic/geec proteins make lung scarring diseases worsen and important lung repair cells cannot develop properly. This suggests the process plays a crucial role in maintaining lung health. Interestingly, disease-causing organisms like the covid-19 virus, HIV, and certain bacteria use this same pathway to enter cells. While this makes cells vulnerable to infection, IT also creates opportunities for delivering therapeutic treatments using specially designed nanoparticles or modified viruses. Understanding how clic/geec endocytosis works at the molecular level could help scientists better comprehend both healthy cell function and disease processes. This knowledge may lead to new drug delivery methods and treatments for lung diseases, making IT an important area for future medical research.

Quick answers

Who received award F31HL186676?

F31HL186676 was awarded to University Of Washington by National Heart Lung and Blood Institute (National Institutes of Health) on December 12, 2026.

How much is award F31HL186676 worth?

$49,637 has been obligated on F31HL186676.

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