Project Grant F31AR087287
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded New York University $148,062 on September 30, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The funded research investigates the mechanism by which epithelial stem and progenitor cells encode inflammatory memory in psoriasis and other remitting-relapsing inflammatory disorders. The study tests whether homeostatic and inflammatory transcription factors dynamically...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded The Regents of the University of California at Riverside $224,100 on September 15, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate epigenetic factors controlling epidermal stem cell longevity in adult skin. The research examines how epigenetic regulators, specifically polycomb repressive complexes, function in hair follicle stem cells and interfollicular...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded $581,451 to Icahn School of Medicine at Mount Sinai on June 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate neuroimmune mechanisms underlying pruritus and microbiota-evoked sensory nerve hyperinnervation. The research examines how commensal microbiota-induced immune responses, particularly T cell immunity to Staphylococcus aureus and IL-17A cytokine...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded Icahn School of Medicine at Mount Sinai $551,321 on July 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate the cellular and molecular mechanisms governing dermal condensate formation during embryonic hair follicle development. The research explores how axon guidance signaling regulates the migration and clustering of dermal papilla cell progenitors...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded Icahn School of Medicine at Mount Sinai $544,559 on September 2, 2026, to investigate basophil-fibroblast interactions in atopic dermatitis under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The project examines how basophil-derived cytokines and mediators activate fibroblasts and drive inflammatory immune cell recruitment in atopic dermatitis. Research employs genetic approaches...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded the University of Texas Health Science Center at Houston $623,286 on July 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate hypoxia-driven NUDT21-mediated alternative polyadenylation in lung and skin fibrosis associated with systemic sclerosis. The project, designated R01AR087804, examines how tissue hypoxia—driven by Raynaud's phenomenon and...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded The Leland Stanford Junior University $204,682 on September 10, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to characterize the roles of RNA-binding protein assemblies in epidermal homeostasis. The recipient will develop and apply two new crosslinking immunoprecipitation-based methods—IRCLIP-RNP and RE-CLIP—to study how RNA-binding proteins organize and...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded the University of California, San Diego $559,827 on September 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate the molecular mechanisms regulating inflammatory responses in epidermal keratinocytes. The research will characterize the role of the ZNF750 protein complex and its associated factors (KDM1A/LSD1, SETDB1, TRIM28/KAP1, and HNRNPU) in mediating...
- The National Institutes of Health National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded the University of California, Los Angeles $493,148 on September 3, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to characterize mechanisms of intra-epithelial migration in the developing epidermis. The project uses live imaging of developing zebrafish to investigate how specialized cell types arising from basal epidermal cells—specifically...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded the University of Texas Southwestern Medical Center $578,211 on August 7, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to fund investigator-initiated research defining how epidermal NADPH depletion and redox imbalance disrupt skin barrier function and drive systemic metabolic effects. The project addresses the physiological roles of NAD kinase (NADK) and NADPH...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), part of the National Institutes of Health, awarded The Rockefeller University $100,228 on November 27, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate whether embryonic exposure to hypoxia primes epidermal stem cells for inflammatory response in postnatal life. The research tests the hypothesis that developmental transcription factor activity, specifically HIF1A induction during fetal epidermal development in the hypoxic intrauterine environment, encodes epigenetic memories that enhance stem-cell responsiveness to inflammatory stimuli after birth. The investigator will modulate HIF1A activity during embryonic epidermal development in mouse models using in utero lentiviral delivery of Cre recombinase to HIF1A conditional-knockout embryos, then characterize resulting molecular changes with focus on the chromatin landscape and stress-induced loci accessibility. Preliminary data indicate that HIF1A is dispensable for skin morphogenesis but drives substantial transcriptional changes in epidermal stem cells, including altered expression of hypoxia-induced target genes and chromatin-modifying enzymes. Place of performance is New York, NY 10065. The period of performance extends from award date through July 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $50.1k | 6/9/26 | ||
| Not listed | $50.1k | 6/9/26 | ||
| Not listed | $0 | 6/9/26 |