Project Grant F31AI200192
- The National Institute of Allergy and Infectious Diseases awarded $430,024 to the University of Pittsburgh on July 8, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate intestinal interactions between Clostridioides difficile and Clostridium perfringens and their impact on gastrointestinal disease pathology. The research addresses the epidemiologic association between these two clostridial pathogens, which frequently co-occur in diarrheic feces of...
- The National Institute of Allergy and Infectious Diseases awarded $182,424 to Trustees of Tufts College (doing business as Tufts University School of Medicine) on October 24, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research on the effect of epithelium association and toxin gene expression on Clostridioides difficile disease severity. The research addresses the mechanisms driving disease severity in C. difficile infection (CDI), the most common...
- The National Institute of Allergy and Infectious Diseases awarded The Regents of the University of California, San Francisco $246,000 on August 17, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop a hidden Markov modeling framework that characterizes the full clinical progression of Clostridioides difficile infection using patient-level electronic health data. The project addresses gaps in current analytic approaches that treat CDI as a single symptomatic...
- The National Institute of Allergy and Infectious Diseases awarded Cincinnati Children's Hospital Medical Center $202,500 on June 16, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855, Project Grant R21AI200165). The award funds basic research examining how peroxisomes and peroxisomal fatty acid β-oxidation regulate CD4+ T cell inflammatory responses and shape disease pathogenesis in inflammatory and autoimmune conditions. The research investigates the role of...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded Cincinnati Children's Hospital Medical Center (doing business as Children's Home Healthcare) a project grant of $486,000 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research into riboregulation of innate immune signaling, specifically the role of RNA in organizing and regulating multiprotein signaling complexes called signalosomes. The research will...
- The National Institute of Allergy and Infectious Diseases awarded the Regents of the University of Minnesota $529,512 on February 20, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to define the mechanism of intoxication of the Clostridioides difficile transferase. The research uses cryogenic electron microscopy, biochemical and biophysical assays, and cellular biology to address two key questions: how toxin assembly is regulated and triggered, and what...
- The National Institute of Allergy and Infectious Diseases awarded the University of Notre Dame $769,354 on May 22, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to elucidate spore germination machinery in Clostridioides difficile and optimize a class of antibiotics called oxadiazoles as spore germination inhibitors. The research addresses recurrent C. difficile infections, which occur in approximately 25 percent of patients and represent a significant source of...
- Federal Project Grant Award Summary Cincinnati Children's Hospital Medical Center received a $441,375 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded August 12, 2025, with a completion date of July 31, 2027. This grant supports investigator-initiated biomedical research examining the transcriptional mechanisms of chronic inflammation in genetically diverse tissue macrophages,...
- The National Institute of Allergy and Infectious Diseases awarded Cincinnati Children's Hospital Medical Center (doing business as Children's Home Healthcare) $703,409 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of the CLIC/GEEC endocytic pathway in virus-containing compartment (VCC) formation and HIV-1 transmission from macrophages. The research defines mechanisms by which myeloid cells internalize HIV-1 particles and...
- Federal Grant Award Summary Cincinnati Children's Hospital Medical Center received a $3.15 million Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded September 1, 2025, with completion scheduled for August 31, 2029. The award supports investigator-initiated biomedical research examining the role of dendritic cell intrinsic unfolded protein response (UPR) pathways in driving...
The National Institute of Allergy and Infectious Diseases awarded the University of Cincinnati's Sponsored Research Services Division $100,224 on December 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of macrophage migration inhibitory factor (MIF)-induced neutrophil extracellular trap formation (netosis) in Clostridioides difficile infection (CDI) severity and identify potential host-derived therapeutic targets. The research addresses the problem that CDI patients treated with antibiotics face high recurrence risk, necessitating novel host-mediated therapies beyond current antibiotic-primary treatment strategies. The project examines whether neutrophil-derived extracellular traps (NETs) cause collateral intestinal epithelial cell damage during CDI and whether MIF drives netosis through an NADPH oxidase-dependent pathway. Aim 1 will determine whether NETs directly promote intestinal epithelial cell apoptosis and disruption of tight junction proteins during CDI. Aim 2 will investigate MIF's role as an upstream driver of netosis via NADPH oxidase-dependent mechanisms. By elucidating the MIF-NET axis in CDI pathogenesis, the research will establish whether this mechanism represents a viable therapeutic target. The award is classified as a Project Grant. Performance occurs at the University of Cincinnati in Cincinnati, Ohio, with an ultimate completion date of July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $50.1k | 6/11/26 | ||
| Not listed | $50.1k | 6/11/26 | ||
| Not listed | $0 | 6/11/26 |