A drosophila model to understand the role of aging macrophages in epithelial wound healing
Active Project Grant Awarded Last action
- Award ID
- F31AG099608
- Recipient
-
The Regents Of The University Of California UEI GS3YEVSS12N6
- Awarding agency
-
National Institute on Aging
National Institutes of Health, Department of Health and Human Services
- Obligated
- $47,655
Award facts
- Assistance listing
- 93.866 Aging Research
- Completion date 0% complete
- Place of performance
- Berkeley, CA 94720, USA
Award details come from USAspending.gov.
Description
- Abstract
- Chronic, unhealing wounds are significant drivers of disease and mortality in older people, and the mechanisms by which wound healing becomes defective with old age are unclear. The immune system plays a central role in maintaining tissue homeostasis even in the absence of infection, and a decline in wound healing coincides with immunosenescence. However, the exact mechanisms that link the two are not fully known. Macrophages, which are nearly ubiquitous throughout the body, have functions that have been highly conserved throughout animal evolution, including between humans and drosophila. In both humans and flies, macrophages are recruited to wound sites, where they mediate RE-epithelialization, fight infection, and repair the basement membrane. Both humans and drosophila share key hallmarks of aging, such as reduced wound healing efficiency and reduced macrophage function. Previous work has implicated macrophages in the decline in wound healing with old age, but the pathways defective in old macrophages that contribute to this decline are unknown. In the proposed project, JAN mikhale cajulao seeks to uncover mechanisms by which aging alters the macrophage response to wounds using a drosophila model of chronic wounding. Using a combination of confocal microscopy, transplantation methods, and transcriptomics, he will determine how the macrophage response to chronic wounds changes in old age, and the pathways responsible for these changes. His first aim will quantify differences in known wound response pathways across age. In the second aim, he will find and validate candidate pathways that mediate this decline. Completion of the proposed research will advance our understanding of epithelial wound healing specifically in the context of old age, where repair is defective and contributes to disease. Macrophages have been linked to this phenomenon, but the mechanisms that govern defective macrophage repair are unknown. JAN's proposed work will revisit our current model of unhealing wounds by linking macrophage decline and tissue maintenance. He will receive important training in advanced imaging and analysis, transcriptomics, and drosophila genetics while developing a deep understanding of epithelial homeostasis as IT relates to immunosenescence and aging.
Quick answers
Who received award F31AG099608?
F31AG099608 was awarded to The Regents Of The University Of California by National Institute on Aging (National Institutes of Health) on January 17, 2027.
How much is award F31AG099608 worth?
$47,655 has been obligated on F31AG099608.
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