Adolescent alcohol, corticosterone exposure, and NLRP3 inflammasome expression
Active Project Grant Awarded Last action
- Award ID
- F31AA033280
- Recipient
-
The Research Foundation For The State University Of New York UEI NQMVAAQUFU53 Part of The Research Foundation For The State University Of New York
- Awarding agency
-
National Institute on Alcohol Abuse and Alcoholism
National Institutes of Health, Department of Health and Human Services
- Obligated
- $69,706
Award facts
- Assistance listing
- 93.273 Alcohol Research Programs
- Completion date 0% complete
- Originally
- Place of performance
- Binghamton, NY 13902, USA
Award details come from USAspending.gov.
Description
- Abstract
- Early life stress is a prominent risk factor for initiation of alcohol use and increased lifetime alcohol consumption. Both adolescent stress and alcohol use increase the risk for developing depression during adulthood, and both exposures negatively influence the neuroimmune system, resulting in a sensitized or exaggerated response to a neuroimmune challenge. However, in rodent models, the interactive effects of alcohol and stress CO-exposure are not widely studied. Because there is a bidirectional relationship among adolescent stress and alcohol use, IT is critical for these exposures to be studied independently as well as simultaneously to capture synergistic or opposing effects. Therefore, one overall goal of the current proposal is to utilize an exposure paradigm that captures both the independent effects of adolescent intermittent ethanol (AIE) and chronic corticosterone (CORT) consumption in the drinking water, a commonly used model to mimic the downstream effects of one primary component of chronic stress by a tractable means. One component of the neuroimmune system that sits at the nexus between chronic stress and ethanol exposure is the inflammasome, nucleotide-binding oligomerization domain-LIKE (NOD-LIKE) receptor protein 3 (NLRP3). The NLRP3 inflammasome is highly expressed in the resident immune cell of the brain, microglia, and NLRP3 inflammasome expression is increased following both stress and ethanol exposures, causing a sensitized cytokine response upon challenge. Increased cytokine expression has been implicated in dopaminergic dysfunction, such as decreased dopamine availability and downregulated dopamine receptor expression, which may explain AIE- or stress-induced dysfunction of reward and motivation pathways as well. Therefore, the overall goal of the proposed studies is to determine the independent and interactive effects of AIE and CORT on 1) neuroimmune function, measured by NRLP3 expression and microglial activation state, and 2) changes to the reward and motivational systems including behavioral measures such as sucrose preference for anhedonia and effort-based decision making (EBDM) for motivation, as well as dopaminergic dysfunction such as expression of δfosb, D1, D2, and DAT. Specifically, whether the NLRP3 inflammasome plays a mechanistic role as a neuroimmune target for future treatment. Overall, this proposal will provide essential scientific and professional development, so enabling me to reach my goal of becoming an independent researcher.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $34,853 | |
| Amendment | $0 | |
| Original award | $34,853 |
Quick answers
Who received award F31AA033280?
F31AA033280 was awarded to The Research Foundation For The State University Of New York by National Institute on Alcohol Abuse and Alcoholism (National Institutes of Health) on December 10, 2026.
How much is award F31AA033280 worth?
$69,706 has been obligated on F31AA033280.
On GovTribe
See this award's full record
- Every transaction and subaward
- The recipient's other awards and teaming partners
- Similar grant awards
- Ask GovTribe AI about this award