Defining the role of bacterial arginine biosynthesis and its byproducts in the life cycle of trichuris muris

Active Project Grant Awarded Last action

Award ID
F30AI202966
Recipient
Awarding agency
Obligated
$55,114

Award facts

Assistance listing
93.855 Allergy and Infectious Diseases Research
Completion date 0% complete
Place of performance
Philadelphia, PA 19104, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
The parasitic whipworm trichuris infects an estimated half a billion individuals worldwide and can result in severe gastrointestinal symptoms, weight loss, and growth retardation. Trichuris parasitic worms hatch within the mammalian intestine following interactions with the host GUT microbiota. Within the intestines, they complete multiple molts prior to releasing immature eggs into the environment. Adult worms lay thousands of eggs daily which results in a sustained environmental presence and makes them challenging to eradicate. These worms have a complex life cycle that critically depends on interactions with the GUT microbiota, yet the precise mechanisms governing these remains poorly understood. Previous work using escherichia coli as a model implicated bacterial arginine biosynthesis in EGG hatching and reproductive maturation of the mouse parasite trichuris muris. The mechanism by which arginine biosynthesis contributes to these stages in the parasite life cycle is not understood. In this project, we will identify byproducts of bacterial arginine biosynthesis that promote T. Muris EGG hatching and define the impact of the pathway in the development and reproduction of the worm using EX vivo hatching assays and gnotobiotic mouse models. In aim 1, we propose to identify how bacterial arginine biosynthesis promotes hatching of T. Muris. We hypothesize that polyamines, which are derived from arginine catabolism, act to promote T. Muris EGG hatching. In aim 2, we will examine how bacterial arginine biosynthesis influences post-hatching T. Muris development and reproductive fitness throughout its life cycle. Findings from these experiments may identify novel metabolic pathways as targets to disrupt the T. Muris life cycle, offering innovative strategies for controlling parasitic helminth infections.

Quick answers

Who received award F30AI202966?

F30AI202966 was awarded to The Trustees Of The University Of Pennsylvania by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on February 14, 2027.

How much is award F30AI202966 worth?

$55,114 has been obligated on F30AI202966.

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