Neurological sequelae of chikungunya virus infection in a genetically susceptible mouse model

Active Project Grant Awarded Last action

Award ID
F30AI202858
Recipient
Awarding agency
Obligated
$81,058

Award facts

Assistance listing
93.855 Allergy and Infectious Diseases Research
Completion date 0% complete
Originally
Place of performance
San Antonio, TX 78229, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Chikungunya virus (CHIKV), a mosquito-borne alphavirus, has caused millions of infections worldwide and is now a growing public health concern not only in endemic regions but also in non-endemic areas. Recent outbreaks in china and LA réunion, along with locally acquired cases in the united states, underscore its expanding geographic range and potential for sustained transmission. While typically associated with arthritogenic disease, CHIKV can also cause persistent neurological and cognitive symptoms in a subset of patients. Despite its global impact, there are no antiviral treatments available, and the mechanisms linking acute infection to long-term neurological sequelae remain poorly understood. This project will define how CHIKV infection induces persistent neurological dysfunction following peripheral infection in collaborative cross strain CC041 mice, a genetically susceptible, immunocompetent model of neuroinvasive disease. Aim 1 will characterize behavioral abnormalities following peripheral CHIKV infection to identify measurable deficits in locomotion, coordination, and memory in mice susceptible to neuroinvasion. Aim 2 will map the spatial and molecular landscape of CHIKV-induced neuropathology using integrated rnascope and spatial transcriptomics to reveal brain region-specific transcriptional changes associated with synaptic dysfunction, neuroinflammation, and repair in susceptible mice. Aim 3 will identify and validate circulating biomarkers of chronic CHIKV-induced neuropathology through proteomic and multiplex analyses of mouse serum and brain samples, then compare these findings with existing human CHIKV datasets to assess shared molecular signatures of neurological injury. Together, these studies will establish the first immunocompetent mouse model that recapitulates persistent neurological outcomes following peripheral CHIKV infection and reveal molecular pathways and biomarkers linking infection to brain dysfunction. Findings will advance the understanding of post-viral neurological diseases, addressing a critical GAP in global health. This fellowship will be carried out within the south texas medical scientist training program at the university of texas at SAN antonio (UTSA) and the texas biomedical research institute (texas biomed/tbri). Together, these institutions offer robust platforms for behavioral neuroscience, neuropathology, spatial omics, and translational biomarker discovery. Guided by experienced mentors and a comprehensive training plan centered on rigor, communication, and interdisciplinary collaboration, this environment will support progression toward an independent physician-scientist career focused on post-viral neurological disease.

Transactions

Action Obligated Date
Amendment $40,529
Original award $0

Quick answers

Who received award F30AI202858?

F30AI202858 was awarded to The University Of Texas Health Science Center At San Antonio by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on February 13, 2027.

How much is award F30AI202858 worth?

$81,058 has been obligated on F30AI202858.

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