Project Grant DTFH6111G00009

This Project Grant award of $420,400 from the National Cancer Institute's Cancer Treatment Research program (CFDA 93.395) supports research by the University of Texas MD Anderson Cancer Center to explore cellular resistance mechanisms to second-generation MTA-cooperative PRMT5 inhibitors in MTAP-loss tumor cells. The research aims to address the challenge of innate and acquired resistance observed in 40-60% and 20-30% of MTAP-loss cancer patients, respectively, when treated with these novel...

This $398,750.00 Project Grant awarded by the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) supports a research study on 4-hydroxymandelate (4-HMA) as a potential treatment for two forms of mitochondrial encephalopathy caused by biallelic mutations in the HPDL gene - neurodevelopmental disorder with progressive spasticity and brain white matter abnormalities (NEDSWMA) and autosomal recessive spastic paraplegia 83 (SPG83). The grant will fund a natural history study of...

This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under CFDA 93.865, the Child Health and Human Development Extramural Research program, provides $347,016 to Syntis Bio Inc. to develop SYN-202, an oral methionine-gamma-lyase (MGL) enzyme therapy for the treatment of homocystinuria. Homocystinuria is a rare genetic disorder caused by mutations in the cystathionine-B-synthase (CBS) enzyme, leading to the toxic accumulation...

This Project Grant award of $396,250 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants (CFDA 93.242) program, will support research at Vanderbilt University to investigate the regulation of metabotropic glutamate receptor (mGluR) activity by protein-protein interactions. The research aims to: 1) test a suite of agonists, positive allosteric modulators (PAMs), and negative allosteric modulators (NAMs) for activity at mGluR7 with and without the protein...

This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $236,098 to The Trustees of the University of Pennsylvania to elucidate the glutamatergic mechanisms of repetitive transcranial magnetic stimulation (rTMS) in the treatment of major depressive disorder. The research aims to use cutting-edge ultra-high field (7T) neuroimaging techniques, including glutamate chemical exchange saturation transfer...

This federal Project Grant award from the Defense Health Agency's Military Medical Research and Development program (CFDA 12.420) provides $130,000.00 to The University of Auckland in New Zealand to establish a cell-based model for discovering new molecules that inhibit the degradation of altered SDHB and rescue its tumor suppressor function in paraganglioma and pheochromocytoma (PPGL). The research aims to advance the understanding and treatment of these neuroendocrine tumors. The award...

This Project Grant award from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) provides $1,002,591.00 to Targepeutics, Inc. to determine the intratumoral drug distribution of the immunotoxin GB13 for the treatment of adult and pediatric brain cancers. The 3-year project aims to transform health care for Service Members and the American public through innovative and impactful biomedical research on medical solutions for the battlefield. The...

This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $709,081 to Emory University to conduct research aimed at gaining a deeper understanding of the role of the protein phosphatase 2A (PP2A) in the pathophysiology of Takotsubo syndrome (TTS) and developing novel small molecule activators of PP2A for TTS treatment. The key products and services to be delivered through this 4-year grant, awarded on September 1,...

The Institute of Gas Technology (IGT) was awarded a $200,000 Project Grant from the Department of Transportation Pipeline and Hazardous Material Safety Administration (PHMSA) under the Interagency Hazardous Materials Public Sector Training and Planning Grants program (CFDA 20.703) to deliver hazardous materials emergency preparedness services. The Hazardous Materials Emergency Preparedness Grant (HMEP) aims to increase effectiveness in safely handling hazardous materials incidents and enhance...

The National Center for Advancing Translational Sciences (NCATS), under CFDA Program 93.350, has awarded a $331,034 Project Grant to Vector Surgical LLC to develop the Gene Therapy Catheter (GTC) - an electrical pulsing device designed to enhance the delivery of adeno-associated virus (AAV) gene therapy to the liver. The GTC aims to improve the efficiency and safety of liver-directed gene therapies by combining local delivery with electrical pulsing and a double-balloon system to isolate the...