This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), totaling $1,737,000.00, aims to identify the mitochondrial mechanisms driving learning and memory. The Max Planck Florida Institute for Neuroscience, a non-profit research organization, will conduct this 3-year research project from September 1, 2024 to August 31, 2027. The key objectives are to discover novel regulators that dictate the flexibility of local mitochondrial energy production at the spatial and temporal scales relevant for synaptic plasticity, the cellular basis of learning and memory. The researchers will utilize innovative techniques in subcellular proteomics, CRISPR-based screening, and high-resolution measurement of ATP synthesis and calcium handling in individual dendritic spines and mitochondria. Ultimately, this project seeks to fill the knowledge gap between mitochondrial mechanisms and cognitive behaviors, providing new insights into learning and memory disorders.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $1.7m | 8/30/24 |