Project Grant DP2AI200992
- The National Institute of Allergy and Infectious Diseases awarded The Feinstein Institutes for Medical Research $460,625 on February 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the maturation and maintenance of the germinal center niche, specifically follicular dendritic cells (FDCs). The research determines FDC longevity and turnover in young and aged mice at steady state, post-immunization, and under chronic lupus inflammatory conditions,...
- The National Institute of Allergy and Infectious Diseases awarded The Trustees of Columbia University in the City of New York $3,144,408 on February 6, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate regulatory T cell memory in human tissues. The award funds research to characterize the role, identity, and function of human regulatory T cells (Tregs) across diverse tissues and their interactions with immune and structural cells. The project will...
- The National Institute of Allergy and Infectious Diseases awarded Fred Hutchinson Cancer Center $879,998 on July 15, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of mucosal regulatory T cells in modulating tissue-resident memory T cell responses to infection. The research defines the features, fate, mechanisms, and functional consequences of regulatory T cells (Treg) and tissue Treg in anti-viral tissue memory immune responses in mice and...
- The National Institute of Allergy and Infectious Diseases awarded Albert Einstein College of Medicine $780,787 on January 27, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on how T cell receptor recognition of peptide ligands shapes memory CD8+ T cell programming. The research will identify features of T cell epitopes, T cell receptor structural modes of recognition, T cell receptor signaling pathways, and genetic and epigenetic regulators...
- The National Institute of Allergy and Infectious Diseases awarded Scripps Research Institute $552,000 on August 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct functional characterization of dendritic cell heterogeneity for T cell-inducing immunotherapies. The research addresses vaccine development for intracellular pathogens including HIV/AIDS and malaria by investigating the distinct roles of type 1 and type 2 conventional dendritic cells in...
- The National Institute of Allergy and Infectious Diseases awarded The University of Texas Southwestern Medical Center $249,000 on July 20, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research to develop tools for marginal zone-specific gene expression manipulation in B cells. The project investigates how mature B cell subsets—follicular, marginal zone, and B-1 cells—contribute to protective immune responses in infection and pathogenic responses...
- The National Institute of Allergy and Infectious Diseases awarded the Trustees of Indiana University $710,142 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on CD4 TH1 cell restoration for control of chronic viral infections. The project, awarded as a Project Grant (R01AI190033), runs through August 31, 2031, with place of performance in Indianapolis, Indiana. The research addresses T cell exhaustion driven by prolonged...
- The National Institute of Allergy and Infectious Diseases awarded the University of Maryland, Baltimore $455,500 on February 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to characterize a cord-blood specific subset of human gamma-delta T cells with distinct functional features. The research addresses infant vulnerability to intracellular pathogens by elucidating the functional heterogeneity of VD2 T cells in neonates and early infancy. Using spectral flow...
- The National Institute of Allergy and Infectious Diseases awarded The Trustees of Columbia University in the City of New York $622,850 on September 2, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the heterogeneous functions, antigen specificities, and lipid antigen restrictions of human CD4-/CD8- double-negative T cells (DN T cells). The research examines how CD1-restricted DN T cell populations respond to CD1-presented self-lipid antigens and...
- The National Institute of Allergy and Infectious Diseases awarded New York University $508,500 on April 22, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research investigating how myeloid cells, particularly neutrophils, regulate plasma membrane homeostasis to control decisions between functional immune programs including migration, phagocytosis, and netosis. The research, conducted as a postdoctoral project at New York University School of Medicine...
The National Institute of Allergy and Infectious Diseases awarded Versiti Blood Health, Inc. $510,000 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research on cellular and molecular regulation of tissue-resident memory CD8+ T cell proliferation. The project investigates how tissue-resident memory CD8+ T cells maintain their capacity for lifelong cell cycling and self-renewal independent of circulating immune populations. The research characterizes the cellular and molecular dynamics of T cell division to identify regulatory mechanisms as potential therapeutic targets. The applicant's hypothesis posits that tissue-resident memory CD8+ T cells proliferate via a hybrid state, enabling individual cells to exhibit both stem cell-like proliferation and advanced differentiation for effector functions. The DP2 mechanism funding accelerates innovative research unlikely to receive support through traditional mechanisms and supports the applicant's newly independent research group, which began in August 2025. Work is performed in Wauwatosa, Wisconsin, with a period of performance extending from September 1, 2026, through August 31, 2031. The award is structured as a Project Grant, the standard assistance type under this NIH program.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $510.0k | 8/25/26 |