Project Grant DP2AI200973
- The National Institute of Allergy and Infectious Diseases awarded Dartmouth-Hitchcock Clinic a cooperative agreement of $561,873 on July 24, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on bile acid control of commensal-specific immune responses. The funded research investigates how bile acids—gastrointestinal metabolites with dual roles in lipid absorption and cell signaling—dynamically engage nuclear receptors and GPCRs to modulate...
- The National Institute of Allergy and Infectious Diseases awarded the University of Pennsylvania $100,228 on October 15, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855), to conduct a prospective cohort study examining prenatal diet and childhood atopic dermatitis risk. The project, designated F31AI198148, is the first U.S.-based prospective cohort study investigating the relationship between maternal nutritional exposures during pregnancy and atopic dermatitis...
- The National Institute of Allergy and Infectious Diseases awarded Dartmouth-Hitchcock Clinic $232,500 on February 9, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop and deploy multiplexed reporter platforms for mapping interactions between bile acid pools and nuclear receptors. The funded work builds multiplex nuclear receptor reporter systems capable of identifying ligand-receptor binding across all 48 human nuclear receptors using physiologically...
- Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $5.18M to the University of California, San Diego under the Allergy and Infectious Diseases Research program (CFDA 93.855) on September 5, 2025, with completion scheduled for August 31, 2029. This research initiative investigates the relationship between skin microbiome composition and the development of allergic diseases, specifically atopic dermatitis (AD) and food allergy (FA),...
- The National Institute of Allergy and Infectious Diseases awarded Trustees of Dartmouth College $630,677 on February 2, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate Aspergillus fumigatus persistence within alveolar macrophages and its role in driving chronic aspergillosis. The research addresses host-pathogen interactions that enable persistent fungal infection in the lungs, particularly in people with cystic fibrosis (PWCF) who develop allergic...
- The National Institute of Allergy and Infectious Diseases awarded Trustees of Dartmouth College $100,228 on November 19, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate G-protein signaling mechanisms in Aspergillus fumigatus colony morphology and aerobic glycolysis. The research employs CRISPR-Cas9 genetic techniques to explore epistatic relationships between BAFA, GPAA, G-protein coupled receptors, and H-morph colony morphology in the pathogenic...
- The National Institute of Allergy and Infectious Diseases awarded Trustees of Dartmouth College $100,228 on February 4, 2027, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of alveolar macrophage mitochondria and peroxisomes in antifungal immune responses against Aspergillus fumigatus infections. The research addresses how mitochondria and peroxisomes regulate interferon type I and III production in alveolar macrophages exposed to the fungal...
- The National Institute of Allergy and Infectious Diseases awarded Massachusetts General Hospital $776,034 on February 9, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to decode the neuroimmune control of cutaneous gamma-delta T cell function in allergic immunity. The research investigates a bidirectional neuroimmune circuit involving sensory neurons and epidermal gamma-delta T cells (GD3S) in allergic skin responses. The study integrates cellular immunology,...
- The National Institute of Allergy and Infectious Diseases awarded a cooperative agreement totaling $564,548 to the Regents of the University of Michigan on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research into how bone-marrow multipotent progenitors bearing the FcεRI receptor drive mast-cell–mediated allergic responses at mucosal sites. The project addresses the gap between current therapies that target downstream mast-cell...
- The National Institute of Allergy and Infectious Diseases awarded a cooperative agreement to Michigan State University (doing business as Henry Ford Health+Michigan State University Health Sciences) for $784,314 on June 24, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research investigating the connection between cord blood DNA methylation (DNAM) and early-onset pediatric atopic dermatitis, with particular attention to how in utero environmental...
The National Institute of Allergy and Infectious Diseases awarded Dartmouth-Hitchcock Clinic $443,825 on August 11, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the functional role of the skin mycobiome in atopic dermatitis, particularly head and neck disease subtype. The research addresses a critical gap in understanding how fungal communities contribute to atopic dermatitis pathogenesis. While bacterial microbiome dysbiosis in atopic dermatitis has been extensively studied, the functional mechanisms of skin fungi remain poorly characterized. Head and neck atopic dermatitis affects over one-third of adult atopic dermatitis patients and shows resistance to emerging biologic therapies such as dupilumab. The project hypothesizes that altered atopic skin conditions select for functionally distinct fungal communities that reshape microbial interactions and host responses, thereby driving disease progression. The research plan includes two primary aims. Aim 1 will define the composition and functional heterogeneity of head-and-neck-atopic-dermatitis-associated fungi using integrated metagenomics, culture-based genomics, and high-throughput phenotyping. Aim 2 will establish co-culture platforms to test how atopic skin conditions rewire fungal-fungal and fungal-bacterial interactions, characterized through metabolomics and transcriptomic analysis. Performance occurs in Lebanon, New Hampshire. The period of performance runs from the award date through July 31, 2031. This is a project grant, the standard assistance type under the Allergy and Infectious Diseases Research program.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $443.8k | 8/12/26 |