Project Grant DP2AI192430
- The National Institute of Allergy and Infectious Diseases, a component of the Department of Health and Human Services, awarded $148,614 to Massachusetts Institute of Technology on January 14, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The recipient will develop glycopolymers designed to enhance interactions between immune cells and pathogenic bacteria, creating "cellular glues" that leverage the body's innate immune mechanisms as an alternative to...
- The National Institute of Allergy and Infectious Diseases awarded Emory University $161,244 on April 16, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct experimental evolution assays elucidating evolutionary trajectories to antibiotic resistance in Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli, and how the immune system modifies these trajectories. The research uses in vivo adaptive laboratory evolution experiments in Galleria...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Boston College $2.5 million under the Allergy and Infectious Diseases Research program (CFDA 93.855) for a four-year project (August 1, 2025 – July 31, 2029) investigating the replication and evolution of primate lentiviruses. The research will employ comparative virological, biochemical, and structural (cryo-electron microscopy/electron tomography) approaches to establish...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Boston College $426,250 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for a two-year project period from August 1, 2025, through July 31, 2027. The grant funds investigator-initiated biomedical research aimed at elucidating the function of two conserved peroxisome-derived proteins, PEX4 and PEX22, in apicomplexan parasite membrane transport and host cell...
- The National Institute of Allergy and Infectious Diseases awarded Albert Einstein College of Medicine a Project Grant totaling $1,486,296 on August 12, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research into the human antibody response to Cryptococcus neoformans and survival outcomes in HIV-associated cryptococcal meningoencephalitis, a devastating opportunistic infection of the central nervous system that occurs predominantly in people...
- The National Institute of Allergy and Infectious Diseases awarded $255,000 to the California Institute of Technology on June 8, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop early-stage technology enabling rigorous and reproducible fungal metatranscriptomics in human vaginal samples. The project addresses the challenge that fungal diseases cost the U.S. an estimated $11 billion annually, yet pathogenesis of many fungal diseases remains poorly...
- The National Institute of Allergy and Infectious Diseases awarded Massachusetts Institute of Technology $100,228 on November 7, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). MIT will conduct research examining the molecular basis of T cell allorecognition in graft-versus-host disease and graft-versus-leukemia. The research uses a repertoire-scale examination to determine the molecular mechanisms underlying T cell recognition of non-self major...
- The National Institute of Allergy and Infectious Diseases awarded University of Massachusetts Medical School $139,968 on September 30, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the relationship between genetic variants, transcriptional responses, and Mycobacterium tuberculosis infection outcomes in macrophages derived from genetically diverse Collaborative Cross mice. The research explores how polymorphisms such as those in the STAT2 locus...
- The National Institute of Allergy and Infectious Diseases awarded Massachusetts General Hospital $776,034 on February 9, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to decode the neuroimmune control of cutaneous gamma-delta T cell function in allergic immunity. The research investigates a bidirectional neuroimmune circuit involving sensory neurons and epidermal gamma-delta T cells (GD3S) in allergic skin responses. The study integrates cellular immunology,...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $489,500 Project Grant to The Children's Hospital Corporation (Boston Children's Hospital) on July 9, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The project, titled "Overcoming Obstacles in Structural Elucidation of B Cell Antigen Receptor Assembly and Lateral Interaction," will be conducted through June 30, 2027, in Massachusetts. The research...
The National Institute of Allergy and Infectious Diseases awarded Boston College $465,000 on September 2, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research into the evolution-inspired molecular basis of fungal recognition by mammalian immune receptors. The project applies evolutionary frameworks to understand how mammalian innate immune systems recognize and respond to pathogenic fungi. The research combines testing of naturally diversified immune receptor orthologs with evolution-guided mutational scanning to reveal sequence determinants governing fungal recognition, addressing a gap in the existing literature that has focused extensively on viral and bacterial pathogens but largely overlooked the evolutionary dynamics of host-fungal interactions and their mechanisms. The award funds research performance in Massachusetts through August 31, 2031. The project is classified as a Project Grant under the Allergy and Infectious Diseases Research program, which supports biomedical research and research training in infectious diseases and related areas at public and private nonprofit institutions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $465.0k | 9/2/26 |