Project Grant 60NANB16D265

This $315,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) is supporting the development of chemoenzymatic methods and reagents to produce affordable glycosphingolipids (GSLs), a class of lipids with complex carbohydrate structures that are ubiquitous in cell membranes. The key objectives are to: 1) expand the inventory of commercially available recombinant glycosyltransferase enzymes...

The National Institute of General Medical Sciences (NIGMS) awarded a $306,710 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Z Biotech, LLC to develop a glycan binding protein (GBP)-based glycosylation analysis system. The project aims to address limitations in current glycan structure analysis methods by: Collecting a large glycan array dataset to improve prediction of glycan binding affinities; Expanding coverage of glycan epitopes by supplementing with additional...

This $575,000 project grant awarded by the National Science Foundation's (NSF) Division of Chemistry (CFDA 47.049 - Mathematical and Physical Sciences) will support a research effort led by Professor George O'Doherty at Northeastern University to develop novel synthetic methods for the asymmetric synthesis of oligosaccharide structures. The project aims to enable the efficient, de novo construction of both natural and unnatural oligosaccharide motifs, which have important applications in biology...

The National Institute of General Medical Sciences (NIGMS), through its Biomedical Research and Research Training program (CFDA 93.859), awarded a $325,500 project grant to Trustees of Boston College to support the chemical synthesis of biologically significant polysaccharides via living polymerization. The project aims to develop a platform for the scalable synthesis of various polysaccharides, including linear and branched glucan, mannan, arabinan, arabinomannan, poly-N-acetylglucosamine,...

The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $313,827 Project Grant to Lectenz Bio, Inc. in Georgia. The grant supports the development of "innovative glycan-specific reagents to accelerate the detection of disease biomarkers". Specifically, the project aims to engineer a high-affinity reagent derived from a glycan-processing enzyme to detect high-mannose glycans, which are known...

The National Institute of General Medical Sciences (NIGMS) awarded a $413,036 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Arizona State University (ASU) to develop a new single-molecule sequencing method for glycosaminoglycans (GAGs) using fluorophore-labeled lysosomal GAG degradation enzymes. GAGs are a family of complex polysaccharides with diverse biological functions, but their analysis has been challenging due to their size, complexity, and...

The National Institute of General Medical Sciences (NIGMS) awarded a $347,086 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of California, San Diego (UCSD) to develop "Precision, Functional Glyconanoassemblies Through Supramolecular Design." This research aims to advance the state-of-the-art in synthetic glycan assemblies by employing a coordination-driven self-assembly approach to create multivalent glycomolecules with atomic...

This federal Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program provides funding of $574,999 to Professor Justin Ragains of Louisiana State University to develop new approaches for the efficient, cost-effective synthesis of glycosidic bonds using visible light and earth-abundant reagents. The research aims to advance the fundamental understanding of chalcogen, halogen, and pnictogen bonding and their associated photochemistry...

This $306,782 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the continued development and validation of a panel of six sialoglycan-recognizing probes (SGRPs) by Z Biotech, LLC. The project aims to optimize these specialized molecular tools, which leverage naturally evolved microbial sialoglycan-binding proteins, for use in common laboratory techniques like ELISA, Western...

This Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training) provides $454,478 to The Johns Hopkins University for a project titled "Perfecting Tools to Define the Glycan-Protein Interactome". The project aims to develop advanced chemical probes and computational techniques to map the interactions between glycans (sugar structures) and proteins, which play critical roles in regulating cell physiology and...