Project Grant 2622584
- The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded The Administrators of Tulane Educational Fund (Tulane University) $270,855 on April 1, 2026, under the Engineering program (CFDA 47.041) to develop new catalyst designs that improve reaction selectivity in biomass conversion. The project, performing in New Orleans, Louisiana through March 31, 2029, will investigate how isolated early transition metal atoms embedded within copper-,...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded Tulane University $504,681 on June 1, 2026, under the Biological Sciences program (CFDA 47.074) to develop a biophysical framework linking intramolecular energy flow to enzyme function and rational enzyme evolution. The research seeks to uncover how energy flows from solvent into proteins to enable and regulate their activity, providing a foundation for designing more efficient and versatile enzymes applicable...
- The National Science Foundation (NSF) awarded a $340,000 Project Grant under its Mathematical and Physical Sciences (CFDA 47.049) program to The Administrators of the Tulane Educational Fund, doing business as Tulane University. Researchers at Tulane University and Tufts University will perform computational and experimental investigations using quantum chemistry, machine learning, and atomic-scale characterization to identify and develop a novel class of "dual-atom alloy" catalysts....
- Federal Project Grant Award Summary Tulane University received a $750,000 project grant from the National Science Foundation (NSF) under the Mathematical and Physical Sciences program (CFDA 47.049), effective September 1, 2025 through August 31, 2028. The award, administered through the Chemical Theory, Models and Computational Methods Program in the Division of Chemistry, supports the development of improved density functional theory (DFT) approximations at higher levels of the computational...
- The National Science Foundation awarded Tufts University a $583,993 project grant under the Engineering program (CFDA 47.041) to develop superoptimal biocatalysts for the period of October 1, 2022 to September 30, 2025. The university will evaluate a new computational and materials-based strategy to design enzyme variants with improved properties without trade-offs by relaxing stability criteria and targeting non-cognate substrates. Tufts researchers will use directed evolution and deep...
- The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded the University of California, Los Angeles $625,000 on September 1, 2026, for mining and engineering new biocatalysts for sustainable chemoenzymatic synthesis under the Engineering program (CFDA 47.041). The project will discover and characterize ATP-grasp and amide bond synthetase enzymes from fungi that catalyze carbon-nitrogen bond formation under mild reaction conditions. These...
- The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded the University of Florida $438,528 on April 1, 2026, under the Engineering program (CFDA 47.041) for collaborative research on dilute-alloy catalysts that selectively promote hydrodeoxygenation of lignan-derived compounds from plant-based biomass. The project develops new catalyst designs that control atomic-scale structure to improve reaction selectivity, reducing unwanted side...
- The National Science Foundation (NSF), through its Mathematical and Physical Sciences Federal Grant Program (CFDA 47.049), awarded The Administrators of Tulane Educational Fund (Tulane University) a $284,240 Project Grant to study synthetic molecules relevant to the Earth's nitrogen cycle. The 5-year research project, which began on June 1, 2025, aims to prepare and investigate new terminal hydride complexes of manganese and iron, particularly those with electron counts pertinent to the...
- This $188,000 Project Grant award from the National Science Foundation (NSF) Office of Integrative Activities (CFDA 47.083) will support the acquisition of a Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometer (MALDI-TOF MS) at Tulane University in New Orleans. The new high-resolution, tandem mass spectrometry instrument will be utilized by researchers across the departments of Chemistry, Chemical Engineering, and Physics at Tulane, as well as at the participating...
- The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded the University of California Irvine $343,554 on May 1, 2026, to develop a directed evolution workflow for surface-displayed enzymes on bacterial spores under the Engineering assistance program (CFDA 47.041). The project will identify enzymes that function under harsh chemical processing conditions—high temperatures, extreme pH values, and organic solvents—by leveraging the...
The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded Tulane University $439,707 on November 1, 2026, under the Engineering program (CFDA 47.041) to map structural coupling networks that control enzyme catalysis and improve understanding of enzyme function for industrial applications. The project uses combined experimental and computational approaches to uncover functional relationships between enzyme structure and catalytic performance, with fluorinase as the model enzyme. Work includes time-resolved hydrogen-deuterium exchange mass spectrometry to map mutation- and substrate-induced changes in protein structural dynamics, enzyme kinetics to quantify effects on catalytic efficiency, molecular dynamics simulations and residue-network analysis to identify signal-transmission pathways across the enzyme, and iterative cycles of computational prediction and experimental validation guided by combinatorial mutagenesis and high-throughput screening. Machine learning-assisted optimization will generate sequence-activity datasets to improve catalytic variants. The project also trains students in biophysical chemistry, mass spectrometry, computation, and data science, and delivers K–12 outreach and public activities highlighting research and biotechnology careers. Work is performed in New Orleans, Louisiana, through October 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $439.7k | 8/13/26 |