Project Grant 2621756
- This Project Grant award from the National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems (CFDA 47.041 - Engineering) supports a $320,155 research project at Purdue University to investigate the complex flow and transport processes within microvascular networks and their impact on vascular remodeling. The key objectives are to develop a novel computational model integrated with high-resolution imaging data to gain fundamental understanding...
- The National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation awarded San Diego State University Foundation $215,001 on September 1, 2026, to develop an integrated experimental and computational framework characterizing coronary blood vessel mechanics and their interaction with cardiac muscle under healthy and diseased conditions. The research will establish a multiscale model coupling coronary blood flow with cardiac mechanics, incorporating vascular impedance...
- The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded $199,934 to the University of Maryland Eastern Shore on June 1, 2026, under the Engineering program (CFDA 47.041) to develop an impedimetric immunosensor platform for characterizing phagocytosis. The award funds development of a compact, label-free biosensing platform that measures phagocytic activity by tracking electrical changes in cells as they recognize, engulf, and process...
- The National Heart, Lung, and Blood Institute awarded the Regents of the University of Michigan $724,200 on July 10, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate endothelial cell fate switches and dysfunction driven by fibrotic matrix remodeling. The research uses mouse models and an in vitro human microphysiological system of arteriole and venule-scale microvessels embedded within tunable stromal mimetic matrices to demonstrate how fibrotic physical cues...
- This $100,000 Project Grant from the National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems supports the development of a 3D human stem cell cardiac model for cardiac electrophysiology medical device safety assessment. Funded under the NSF Engineering program (CFDA 47.041), this award will allow the University of Maryland, College Park to create a novel in vitro model for evaluating the safety and efficacy of cardiac medical devices through January...
- This $262,138 Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) supports research at the University of Houston to investigate the mechanisms of cardiac fibrosis, a type of scarring in the heart that leads to impaired function. The key objectives are to: 1) determine the role of the endothelial-mesenchymal transition in cardiac fibrosis, and 2) develop a 3D cardiac fibrosis model to study tissue remodeling. The research will leverage a...
- The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded Southeast Missouri State University a $199,895 Project Grant under the Engineering (47.041) federal grant program. The two-year award will support research into using opto-magnetic stimulation and energy-harvesting nanodevices to restore endothelial cell functioning damaged by oxidative stress and chronic disease. The university researchers will develop multifunctional nanoscale...
- The National Science Foundation (NSF) awarded a $437,038 Project Grant under the Engineering program (CFDA 47.041) to the University of Massachusetts (UMass) to develop a technology for targeted electrical stimulation of endothelial cells lining blood vessels. The objective is to modulate endothelial cell function to enhance drug delivery to tumors and improve treatment outcomes for cancer patients. The 5-year project will study pulsed electric field waveforms that can selectively alter...
- This National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET) project grant award provides $598,884 over 4 years to The Regents of the University of California, doing business as the University of California, Berkeley, to develop a novel suite of simulation tools for modeling vascular biomechanics and mechanobiology as part of the open-source SimVascular software platform (CFDA No. 47.041 Engineering). The project aims to enhance...
- The National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation awarded Vanderbilt University Medical Center a $300,000 Project Grant under the Engineering (47.041) federal grant program. The three-year award, issued on June 1, 2021 and concluding on May 31, 2024, will support collaborative research to understand the effects of flow on smooth muscle cells in an arteriole-sized microchannel. Specifically, VUMC will analyze flow conditions and interactions at the...
The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded the University of Maryland Baltimore County $471,305 on September 15, 2026, under the Engineering program (CFDA 47.041) to develop a microfluidic model and metabolomic analysis framework investigating why diabetic patients face elevated cardiovascular disease risk despite controlled blood glucose levels. The project will construct a laboratory model using real human artery tissues and advanced microfluidics technology to replicate both healthy and diabetic blood vessel conditions, focusing on long-lasting structural changes in the extracellular matrix (ECM) that current research models do not accurately mimic. Using metabolomics to study small molecules in cells, the research will identify how ECM remodeling disrupts endothelial cell function and contributes to vascular disease. The work employs modular, high-throughput microfluidic endothelium models using decellularized human artery tissues as physiologically relevant ECM scaffolds. The project runs through August 31, 2029, with place of performance in Baltimore, Maryland. Beyond research outcomes, the award supports hands-on training for graduate, undergraduate, and high school students, with educational outreach to the local community. The model and findings may inform treatment and prevention strategies for lingering cardiovascular disease in diabetic populations and support investigations of other diseases involving ECM changes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $471.3k | 7/31/26 |