Project Grant 2534434
- This Project Grant award, provided by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) federal grant program, supports the development and application of oxidative biocatalysts for chiral resolutions and increasing student success in organic chemistry at Sam Houston State University (SHSU). The $555,432 award enables Professor Meagan Hinze in the Department of Chemistry at SHSU to study the use of enzymes, or natural catalysts, to selectively...
- The National Science Foundation (NSF) Division of Chemistry is providing a $315,000 Project Grant award to Muhlenberg College, Rhodes College, and the State University of New York at Cortland to study the catalytic efficiency of L-DOPA 2,3-dioxygenase enzymes. The 3-year collaborative research project, titled "Interrogating Catalytic Efficiency Through Kinetic, Structural and Small-Molecule Guided Investigation of L-DOPA 2,3-Dioxygenases", will systematically modify the size and...
- The National Science Foundation (NSF) Division of Chemistry has awarded a $180,000 Project Grant under the Mathematical and Physical Sciences (CFDA 47.049) program to support a collaborative research project titled "INTERROGATING CATALYTIC EFFICIENCY THROUGH KINETIC, STRUCTURAL AND SMALL-MOLECULE GUIDED INVESTIGATION OF L-DOPA 2,3-DIOXYGENASES." The grant, with an award date of August 1, 2025 and an ultimate completion date of July 31, 2028, will fund a joint investigation by...
- The National Science Foundation (NSF) awarded a $599,999 project grant under the Mathematical and Physical Sciences (CFDA 47.049) program to the University of California, Santa Barbara (UCSB) and the University of Pittsburgh. The 3-year collaborative project aims to investigate the detailed mechanisms and origins of selectivity in recently developed enzymatic reactions with unnatural electron transfer pathways. The research team, led by Professors Yang and Liu, will integrate computational tools...
- The National Science Foundation (NSF) awarded a $513,894 Project Grant under its Mathematical and Physical Sciences program (CFDA 47.049) to Tufts University. This 3-year grant, effective July 1, 2023, supports Professor Clay S. Bennett's research to develop new methods for synthesizing deoxy sugars - an important component of many biologically active natural products. The project aims to expand upon approaches that activate sugar hemiacetals as glycosyl sulfonates or tert-butyldimethylsilyl...
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) provides $287,110 to Hamilton College to develop a new class of chemical compounds called N-quaternized ketene N,O-acetals. These compounds, which were previously considered too unstable for practical use, have recently been made synthetically accessible through the principal investigator's research. The goal of this project is to expand the utility of these compounds in...
- The National Science Foundation (NSF), through its Mathematical and Physical Sciences program (CFDA 47.049), awarded a $600,000 project grant to Professor Neil C. Tomson of the University of Pennsylvania. The 3-year project, starting on September 1, 2025, aims to study how iron-based catalysts can selectively activate and functionalize carbon-carbon sigma bonds under mild conditions. This research will lay the groundwork for future technologies that can produce pharmaceuticals, plastics, and...
- This $447,000 Project Grant from the National Science Foundation's Division of Chemistry, under the Mathematical and Physical Sciences program (CFDA 47.049), will support research at Haverford College from December 2022 through February 2026. The research team, led by Dr. Louise Charkoudian, will investigate type II polyketide biosynthetic enzyme assemblies across bacterial species to leverage their capabilities for sustainable chemical production. Undergraduate students will gain research...
- The National Science Foundation (NSF) is providing a $600,000 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to the Massachusetts Institute of Technology (MIT) for a 4-year research project led by Professor Alexander Radosevich. The project aims to develop inexpensive, earth-abundant chemical catalysts capable of enabling novel bond-making and bond-breaking reactions. Specific research areas include using proton-coupled electron transfer (PCET) to activate C-H...
- This Project Grant award for $450,000 was provided by the National Science Foundation (NSF) through the Mathematical and Physical Sciences (CFDA 47.049) federal grant program. The funding supports collaborative research by Professors Yisong Guo of Carnegie Mellon University and Wei-Chen Chang of North Carolina State University to investigate a group of four enzymes that utilize a single iron atom and molecular oxygen to catalyze diverse chemical reactions. The goal is to elucidate the...
The National Science Foundation (NSF), through its Mathematical and Physical Sciences (CFDA 47.049) program, awarded a $151,966 Project Grant to Randolph-Macon College. This grant, titled "LEAPS-MPS: EXPANDING ASYMMETRIC CATALYSIS WITH THIAMINE-DEPENDENT ENZYMES," will fund a research project led by Professor Reynolds and his students to explore the use of thiamine-dependent enzymes for the stereoselective formation of β-substituted ketones. The key objectives of this project are to: 1) Screen a panel of thiamine-dependent enzymes against substrates with multiple chiral centers to form stereochemically complex products, and 2) Investigate the ability of these enzymes to catalyze reactions through alternative single electron pathways. This research aims to overcome the limited scope of enzymatic reactions and expand the application of these "green" catalysts for sustainable chemical synthesis. The project also incorporates research and mentoring opportunities for underrepresented students in STEM fields, as well as integration into a course-based undergraduate research experience.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $152.0k | 9/12/25 |