I-corps: translation potential of green synthesis of imines and imine-related compounds

Ended Project Grant Awarded Last action

Award ID
2452005
Recipient
Awarding agency
Obligated
$50,000

Award facts

Assistance listing
47.084 NSF Technology, Innovation, and Partnerships
Completion date
Place of performance
Oneonta, NY 13820, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
The broader impact of this I-corps project is the development of an environmentally-friendly and economically-compelling alternative chemical synthesis for imines and their derivatives. Imines are organic chemical intermediates with high-value commercial applications in pharmaceutical, agrochemical, and specialty chemical supply chains. This imine synthesis offers chemical manufacturers a solution that produces high-yield, high-purity imines at a fraction of the time, energy, and cost of traditional industry methods. This I-corps project utilizes experiential learning coupled with a first-hand investigation of the industry ecosystem to assess the translation potential of the technology. This solution is based on the development of a novel green imine synthesis. The technology is an aqueous-based imine manufacturing process that replaces conventional toxic solvents with a renewable, biodegradable solvent that is food and drug administration (FDA)-approved for use as a food additive. This solution allows for imine synthesis under ambient conditions and can be tuned with water as CO-solvent to optimize polarity and induce rapid product formation within seconds to minutes. In contrast, conventional methods of imine synthesis often use petroleum-derived solvents that are flammable, explosive, and potentially harmful to workers and the environment, due to emission of fumes at the temperatures required. The new process has been validated to produce over 400 unique imines and dozens of related compound classes including oximes, azines, semicarbazones, pyrazoles, pyrazolones, quinoxalines, and quinoxalin-2(1H)-ones. The technology has also been validated at lab scale and is projected to scale to commercial manufacturing quantities. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the foundation's intellectual merit and broader impacts review criteria.- subawards are not planned for this award.

Quick answers

Who received award 2452005?

2452005 was awarded to The Research Foundation For The State University Of New York by National Science Foundation on December 15, 2024.

How much is award 2452005 worth?

$50,000 has been obligated on 2452005.

On GovTribe

See this award's full record

  • Every transaction and subaward
  • The recipient's other awards and teaming partners
  • Similar grant awards
  • Ask GovTribe AI about this award
Try for free Login