This Project Grant award of $175,000 from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program (CFDA 47.070) supports the development of a modular framework for modeling the binding of peptides and proteins to cell membranes. The key products to be delivered include: A software "mover" implemented in the Rosetta C++ codebase to predict the placement of proteins and peptides in cell membranes, an application of this mover compatible with the RosettaScripts framework, standalone Python scripts that can be integrated with external modeling tools, and a web server for predicting protein-membrane binding. This work aims to create flexible, robust, and accurate computational tools to model membrane protein structure and function, which are critical for understanding disease mechanisms and developing potential therapies. The award is held by Butler University in Indianapolis, Indiana and is scheduled for completion by July 2026.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $175.0k | 1/29/24 |