Collaborative research: investigating the role and interplay of microenvironment, manufacturing, and metabolism on MSC production of extracellular vesicles
Ended Project Grant Awarded Last action
- Award ID
- 2305874
- Recipient
-
Trustees Of Union College In The Town Of Schenectady In The State Of New York UEI HE9HQBNZHHB5
- Awarding agency
-
Division of Chemical, Bioengineering, Environmental, and Transport System
National Science Foundation
- Obligated
- $86,662
Award facts
- Assistance listing
- 47.041 Engineering
- Completion date
- Place of performance
- Schenectady, NY 12308, USA
Award details come from USAspending.gov.
Description
- Abstract
- Mesenchymal stromal cells (MSCS) are isolated from bone marrow and FAT cells. While they are not stem cells, they exhibit a similar ability to differentiate into many types of cells. That ability forms the basis for developing treatments for a variety of diseases. MSCS also generate extracellular vesicles (EVS). The EVS transport bioactive molecules that prompt cellular-level responses. IT is difficult to manufacture EVS reproducibly. This limits its current therapeutic potential. Changes in local conditions impact MSC-EV production and function. Understanding those impacts is the focus of this project. The project will also promote stem participation of students from underrepresented groups. Many challenges contribute to the lack of successful MSC-EV clinical translation. MSC heterogeneity is a key issue. There are no effective critical quality attributes (CQAS) that predict how a given batch of EVS will perform. There are also no standardized manufacturing approaches for EVS. In addition, there is a knowledge GAP regarding the effects of scaling EV manufacturing with respect to 2D VS. 3D environments. The overall goals of this project are to understand how 3D structure affects EV production and to identify metabolic pathways controlling this response. To accomplish these goals, the project team will: 1) investigate the effects of 3D hydrogel microenvironments on EV function, 2) determine the effects of manufacturing strategies on EVS, and 3) define metabolic changes associated with EV production. IT is anticipated that the mechanisms identified will have relevance for MSC-EVS for different therapeutic applications and for EVS generated by other cell types. This project is jointly supported by the cellular and biochemical engineering program in ENG/cbet and the systems and synthetic biology program in BIO/MCB. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the foundation's intellectual merit and broader impacts review criteria.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $29,874 | |
| Original award | $56,788 |
Quick answers
Who received award 2305874?
2305874 was awarded to Trustees Of Union College In The Town Of Schenectady In The State Of New York by Division of Chemical, Bioengineering, Environmental, and Transport System (National Science Foundation) on June 15, 2023.
How much is award 2305874 worth?
$86,662 has been obligated on 2305874.
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