Project Grant 2127159

This $275,000 Small Business Innovation Research (SBIR) Phase I award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program supports the development of a label-free, high-resolution, high-throughput protein screening platform called Vibrational Spectroscopy with Metasurface Optics (VISMO). The technology aims to enable simultaneous, minute-scale measurement of millions of protein samples, which would dramatically improve the lengthy and costly cycles...

This SBIR Phase I project, awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program, aims to develop a software tool that can efficiently generate drug repurposing development plans. The $294,947 award, effective from July 1, 2024 to June 30, 2025, will enable Percept Biosciences Inc., a small business located in San Diego, CA, to create an automated system that can search multiple databases, mitigate biological and regulatory...

This $274,990 Small Business Innovation Research (SBIR) Phase I award from the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships) supports the development of a physics-based machine learning platform for predicting the crystal structure of small drug molecules. The technology aims to accelerate and reduce the cost of early-stage pharmaceutical research and development by computationally analyzing the crystal structure properties that determine key...

This $283,805 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development of a novel cell-free, high-throughput platform to expedite the engineering of enzymes for biocatalytic 'bioclick' reactions. The primary objectives are to establish an in-house cell-free protein synthesis system for rapid expression of enzyme variant libraries, and to leverage low-cost prenyl-donors to screen...

This STTR Phase I project, awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program, aims to develop a novel tissue-engineered platform for more effective cancer drug screening. The $275,000 award to Vivosphere LLC will fund the development of a 3D hydrogel-based scaffold that provides a more physiologically relevant microenvironment for cancer cell growth and drug response testing, as compared to traditional 2D cell cultures and...

This $999,109 Cooperative Agreement awarded by the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) aims to develop a natural product drug discovery platform based on high-throughput elicitor screening (HITES). The project seeks to uncover novel microbial compounds, including potential new antibiotics and anticancer agents, by activating otherwise "cryptic" biosynthetic pathways in microbes. The 2-year project will...

The National Science Foundation (NSF) awarded a $274,932 Project Grant under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program to Femtofluidics Incorporated, a small business located in Excelsior, MN. The goal of this 8-month SBIR Phase I project is to develop a novel hardware platform that can rapidly and inexpensively synthesize DNA-encoded libraries (DELs) for drug discovery applications. The proposed technology aims to manipulate nanoliter to picoliter volume droplets on...

This SBIR Phase I award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $275,000 to Caravel Bio, Inc. to develop a novel synthetic biology platform for high-throughput directed evolution of spore-displayed enzymes. The project aims to create customizable enzyme solutions for industrial biocatalyst applications by improving key properties like enzyme activity, stability, and loading density. The technology uses a...

This $275,000 Project Grant was awarded by the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084). The funding supports the development of a novel, scalable technology platform to enable high-throughput screening of small molecule and protein interactions. The awardee, Om Therapeutics Inc., aims to demonstrate the ability to screen millions of protein-small molecule interactions in miniaturized, barcoded compartments, reducing the...

This Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports the development of an innovative combinatorial pipeline for discovering anti-GPCR nanobodies. The $303,024 award to Biocognon LLC aims to establish a robust yeast dual biosensor technology platform that can efficiently generate high-quality nanobody immune reagents against G-protein coupled receptors (GPCRs), which...