Awards issued prior to january 20, 2025, were funded under previous administrations and may not reflect the priorities and policies of the current administration.** clostridial dermatitis (CD), also…

Awards issued prior to january 20, 2025, were funded under previous administrations and may not reflect the priorities and policies of the current administration.** clostridial dermatitis (CD), also known as gangrenous dermatitis (GD), is a major problem for the turkey industry in the united states, causing significant financial losses. This disease is mainly caused by two bacteria: C. Septicum and C. Perfringens. C. Septicum can cause high death rates in turkeys, while C. Perfringens not only causes CD but also leads to a deadly intestinal disease called necrotic enteritis (NE), which costs the poultry industry $6 billion annually. Although we developed the first vaccine targeting C. Perfringens-induced NE in 2020, there is still no effective way to control C. Septicum. To solve the problem of CD, we need to target both bacteria. This project aims to help not only the turkey and layer industry but also the entire poultry industry. We will use innovative techniques to tackle C. Septicum. Our licensed vaccine contains two components that target C. Perfringens. We have also found one component that protects against both C. Perfringens and C. Septicum, and two additional components that target C. Septicum. We will use these five components to develop new vaccines that target both bacteria. These vaccines will be delivered orally or through a spray using a harmless form of salmonella to protect turkeys and layers from CD and NE. This project will benefit turkey and layer farmers by improving the efficiency and sustainability of poultry production. IT will also provide valuable data that could help protect against other diseases not covered by this project. Additionally, the vaccine may reduce the spread of salmonella, improving food safety. By preventing CD and NE, we can significantly reduce the need for antibiotics in agriculture. This reduction in antibiotic use helps to prevent the development and spread of antibiotic-resistant bacteria, which is a major concern for both animal and human health. This aligns with USDA goals to support a prosperous agricultural system and provide safe, nutritious food. The project is important for the economy, community, environment, and overall agricultural health.