Project Grant 20236701539000
- The National Human Genome Research Institute (NHGRI) awarded a $339,000 Project Grant (CFDA 93.172 - Human Genome Research) to Rockefeller University to develop GFASTAR, a C++ library and tool suite to aid telomere-to-telomere (T2T) genome assembly. The project aims to advance algorithms and software tools for evaluating and manipulating genome assembly graphs, which are essential for generating high-quality, complete, and accurate T2T reference genomes across multiple species. The GFASTAR...
- This $1,645,076 Cooperative Agreement award from the National Human Genome Research Institute (NHGRI) under the Human Genome Research (CFDA 93.172) program will develop advanced tools and resources to enable new ways to access and understand the human pangenome. The key products and services to be delivered include: Sequence alignment and population genetic analysis methods to rapidly search, compare, and interpret pangenome data, leveraging succinct data structures for scalable pangenome...
- The National Human Genome Research Institute (NHGRI) awarded a $457,920 Project Grant (CFDA #93.172 - Human Genome Research) to The Broad Institute, Inc. to develop a deep reinforcement learning framework for haplotype assembly. Haplotype assembly is critical for understanding human population genetics and disease, as it reconstructs the combination of alleles on maternally and paternally inherited chromosome copies. The Broad Institute, a renowned biomedical and genomic research organization,...
- This Project Grant award of $500,000.00 from the National Science Foundation's Computer and Information Science and Engineering (CISE) program, with a performance period from July 1, 2025 to June 30, 2028, supports research to develop new methods for improving the accuracy and efficiency of genome assembly. The project aims to address key computational challenges in assembling complete genomic sequences from fragmented DNA data, which is critical for enabling scientific discoveries and practical...
- This four-year, $1.3 million project grant from the US Department of Agriculture National Institute of Food and Agriculture's Agriculture and Food Research Initiative (AFRI) program (CFDA #10.310) supports the development of pan-transcriptomes to understand genome-phenome relationships in cattle. The awardee, Washington State University, will construct pan-transcriptomes from four ruminant species including cattle breeds to discover transcriptomic variations driving phenotypic divergence....
- The National Human Genome Research Institute (NHGRI), under the Human Genome Research Federal Grant Program (CFDA 93.172), awarded a $384,418 Project Grant to Xgenomes Corp. on September 25, 2024 to develop a revolutionary DNA sequencing platform. The project aims to create a super-resolution single-molecule sequencing technology that can read short sequence "words" rather than individual nucleotides, enabling one or more orders of magnitude improvements in accuracy and cost over...
- This $2,963,428 Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) aims to develop critical infrastructure and tools for interpreting genomic data. The project will create high-quality genome assembly workflows, comprehensive documentation, and interactive training materials to make these advanced genomic analysis capabilities accessible to a wide audience of biology researchers. This will enable downstream discoveries in areas such as...
- The University of Kentucky Research Foundation received a $765,000 Project Grant award under the USDA's Agriculture and Food Research Initiative (CFDA 10.310) to establish a pan-genome for 13 horse breeds and 3 related equids. The project aims to: Create a pan-genome from haplotype-resolved genome assemblies Annotate the pan-genome using tissue-specific transcriptomic and epigenetic data Develop an integrative genomics portal to provide accessible community data. The project leverages prior...
- This $1.3 million project grant from the US Department of Agriculture's National Institute of Food and Agriculture (NIFA) Agriculture and Food Research Initiative (AFRI) program (CFDA 10.310) supports establishing a cattle and sheep pan-epigenome through December 2025. The University of Vermont is leading efforts to comprehensively characterize epigenomic conservation and diversity in multiple breeds of cattle and sheep by examining DNA and RNA methylation, histone modifications, open chromatin,...
- The Baboon Genotype-Tissue Expression (GTEx) Project is a $1,328,822 Project Grant awarded by the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) to the University of Chicago. The project aims to conduct a large-scale, multi-tissue functional genomic study of gene regulation in baboons. Utilizing the University's unique and extensive collection of 51 diverse tissue types sampled from 60 genetically characterized baboons, the project will leverage bulk and...
THE FIRST GENOME ASSEMBLY FOR A MAMMALIAN GENOME WAS DESCRIBED IN THE YEAR 2000 UPON RELEASE OF THE HUMAN GENOME DRAFT. THIS DRAFT WAS FAR FROM COMPLETE, AND IN THE ENSUING 20 YEARS INCREMENTAL IMPROVEMENTS HAVE BEEN MADE TO THE PUBLIC ASSEMBLY. IN SPRING 2022, A GROUP OF RESEARCHERS REPORTED THE FIRST TRULY COMPLETE, TELOMERE TO TELOMERE (T2T) ASSEMBLY THAT FEATURED AN UNBROKEN SEQUENCE WITH NO GAPS OR UNCERTAIN SEQUENCES. ASSOCIATED ANALYSES REVEALED THE SCOPE OF INFORMATION THAT HAD BEEN PREVIOUSLY MISSED USING LESS COMPLETE VERSIONS OF THE HUMAN GENOME, INCLUDING ADDITION OF THOUSANDS OF PREVIOUSLY UNDESCRIBED GENES. SUBSEQUENT UNPUBLISHED REPORTS HAVE DEMONSTRATED THE VALUE OF COMPARATIVE ANALYSIS BETWEEN CLOSELY RELATED SPECIES. THE RUMINANT GROUP OF ORGANISMS, THAT INCLUDES CATTLE, SHEEP, AND GOAT AS WELL AS A VARIETY OF DEER AND ANTELOPE SPECIES, IS OF INTEREST FOR AGRICULTURAL AS WELL AS EVOLUTIONARY REASONS. WE BELIEVE THAT COMPARISONS BETWEEN COMPLETE GENOMES OF RUMINANT SPECIES WILL INFORM OUR UNDERSTANDING OF THEIR EVOLUTION, SHED LIGHT ON GENOMIC CONSEQUENCES OF DOMESTICATION, AND ENHANCE UNDERSTANDING OF FUNCTIONAL ROLES OF ALL OF THE DNA IN THE GENOME. THE WORKSHOP IS INTENDED TO PROVIDE A PLATFORM FOR THE HUMAN T2T RESEARCH COMMUNITY TO TRANSFER KNOWLEDGE AND EXPERTISE IN A FOCUSED FORUM BEYOND THAT POSSIBLE IN LESS FOCUSED SCIENTIFIC CONFERENCES.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $45.3k | 1/12/23 |