Project Grant 2017DNBX0140

This Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) aims to develop a revolutionary DNA sequencing platform that surpasses existing technologies in accuracy and cost. The $384,418 award to Xgenomes Corp. will fund the development of a super-resolution single-molecule sequencing method that can read short sequence "words" rather than single nucleotides, enabling highly accurate and cost-effective genomic analysis. The...

Micropure Genomics Inc. received a $274,199 Project Grant award from the National Science Foundation to advance methods for rapid, end-to-end sample preparation for sequencing applications. Under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084), the company will develop an automated process relying on electro-hydrodynamic trapping to isolate genomic material like DNA or RNA from cells in a flow cartridge. The process aims to significantly reduce preparation time while...

Sequegenics LLC received a $251,073 Project Grant award from the National Science Foundation Division of Industrial Innovation under the Engineering federal grant program (CFDA 47.041). The grant supports development of low-cost and scalable methods for creating genomic databases using long-read next-generation DNA sequencing technologies. This aligns with the program's goals of fostering innovation in engineering research. The one-year project period runs from August 1, 2021 through July 31,...

This Project Grant award from the National Human Genome Research Institute (NHGRI), under the Human Genome Research program (CFDA 93.172), provides $314,538 to Dnali Data Technologies, Inc. to advance the commercial potential of a novel enzymatic technology for producing chemically modified synthetic DNA. The key objectives are: 1) creating modified DNA products that are not currently available from any existing vendor, 2) developing an innovation to eliminate the most costly reagent in the...

This Project Grant award, valued at $215,088, was provided by the National Human Genome Research Institute (NHGRI) under the Human Genome Research Federal Grant Program (CFDA 93.172). The grant supports the development of an "exhaustive de novo RNA sequencing method" by Directseq Biosciences, Inc., a small disadvantaged business based in Schenectady, New York. This innovative technology, referred to as Next-Generation Mass Spectrometry-based Sequencing (NGMS-SEQ), aims to...

This $256,000 National Science Foundation Engineering grant supports the development of an easy RNA adenylation method for deep sequencing of picogram RNA samples with high resolution. Specifically, Ezrabio Inc. will develop a versatile and cost-effective library construction technology that enables protein translation monitoring on a variety of biological samples. The proposed technology relies on a novel enzyme system capable of 5' adenylation and 3' polyadenylation of RNA fragments to...

This $406,500 federal Project Grant from the National Human Genome Research Institute (NHGRI), under the Human Genome Research program (CFDA 93.172), aims to advance "Next-Generation Mass Spectrometry-based Sequencing (NGMS-SEQ)" methods for high-throughput, bias-free sequencing and quantitative mapping of RNA modifications. The funded research seeks to: 1) enhance NGMS-SEQ techniques to directly sequence tRNA samples, including physiologically relevant ones, and 2) improve...

This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $1,507,500 in funding to the University of Massachusetts Medical School (UMass Medical) to expand the capabilities of third-generation sequencing technologies like nanopore sequencing. The primary objectives are to: 1) Generate training libraries to allow for direct detection of common damaged DNA bases resulting from oxidation or...

This Project Grant award from the National Institutes of Health's National Human Genome Research Institute provided $768,678 to Molecular Assemblies, Inc. to develop a fully enzymatic oligonucleotide synthesis cycle using engineered template-independent polymerases and a novel phosphate dNTP blocking group. The award supports the goals of the Human Genome Research program (CFDA 93.172) to accelerate genome research and its application to human health. Specifically, the awardee will engineer...

This federal Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) is focused on developing an innovative nanopore sequencing technology to more accurately detect and quantify RNA modifications in human transcriptomes. The $3,037,222 award to Thomas Jefferson University aims to leverage the poliovirus RNA-dependent RNA polymerase (3DPOL) to enable "twice reading" of RNA molecules, providing improved accuracy in detecting...