Project Grant 2014262

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the federal Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to establish the feasibility of cell-type specific modulation of the blood-brain barrier (BBB) using a novel "MagnetoBBB" approach. The total award amount is $447,501.00 with a project period from September 1, 2024 to August 31, 2026. The key objectives are to: 1)...

This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), will support the development of ultra-high precision image-guided incisionless transcranial ultrasound surgery technologies. The $2,278,167 award, effective August 20, 2024 through April 30, 2028, will enable the University of North Carolina at Chapel Hill (UNC-Chapel Hill)...

The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $543,959 Project Grant (CFDA 93.286 - Discovery and Applied Research for Technological Innovations to Improve Human Health) to the Regents of the University of Michigan on January 15, 2025. The goal of this 4-year project is to develop a Transcranial Magnetic Resonance (MR) and Ultrasound (US) Guided Histotripsy (TCMR-USGHT) system for the non-invasive treatment of brain tumors. The proposed research aims to...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a 3-year, $3,582,963 Project Grant under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372) to Carnegie Mellon University (CMU). The grant supports the development and validation of novel wearable transcranial focused ultrasound (TFUS) neuromodulation transducer array probes compatible with simultaneous electrophysiological recordings in behaving...

This $399,358 Project Grant awarded by the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) to Cordance Medical Inc. aims to optimize a non-invasive focused ultrasound system, called the "NeuroAccess System," to enable liquid biopsies for brain tumor patients. The key objectives are to demonstrate the safety of repeatedly opening the blood-brain barrier, optimize the opening volume and technique in a rat glioma model, and confirm the system's ability to...

This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research program) provides $618,912 to Dynaflow, Inc., a minority-owned small business, to develop a numerical platform for modeling microbubble-enhanced sonothrombolysis. The platform aims to accelerate the clinical deployment of this non-invasive ultrasound treatment for thrombosis, a leading cause of death and disability. Key objectives include incorporating viscoelastic clot...

This Project Grant award, with a total funding amount of $423,151.00, was provided by the National Science Foundation's Engineering program (CFDA 47.041) to Duke University. The goal of this award is to develop a new and transformative functional brain imaging technology that allows continuous, real-time monitoring of neural activities of the entire brain at a micron-scale through an intact skull. The key technical thrusts of the project include: 1) Improving the temporal resolution of...

This Small Business Innovation Research (SBIR) Phase I project, awarded by the National Science Foundation (NSF) under the TIP (Technology, Innovation, and Partnerships) program (CFDA 47.084), aims to develop a novel, multifunctional neural probe for advancing neuroscience research. The $254,456 grant awarded to Neurobionics Inc. on August 15, 2024, will fund the integration of electrical, optical, and chemical capabilities into a single implantable device. This versatile tool will enable...

Cordance Medical Inc. received a $998,501 cooperative agreement award from the National Science Foundation under the Engineering program (CFDA 47.041) for the period of July 15, 2021 through June 30, 2023. The award will support Cordance Medical's efforts to develop transcranial dynamic focused ultrasound for the non-invasive opening of the blood-brain barrier, allowing targeted delivery of therapeutic agents to the brain. The Engineering program seeks to improve quality of life and economic...

The National Science Foundation's (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded a $274,975 Project Grant to Worcester Polytechnic Institute (WPI) under the NSF Engineering program (CFDA 47.041) to investigate the role of microbubbles in improving the efficacy of high-intensity focused ultrasound (HIFU) therapy. The key objectives are to develop a well-controlled in vitro experimental setup to study temperature elevation in tissue phantoms with and...