Project Grant 1951261

This Cooperative Agreement award, funded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program, aims to develop a bioprocessing system to isolate and purify therapeutic antibodies directly from cell culture. The $999,998 award to Athem LLC, a minority-owned small business, will enable scaling up a novel nanoparticle-based purification media and an automated prototype system. The goal is to simplify the manufacturing of biologics, reduce...

This Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) will develop a novel membrane separation technology to address the energy-efficient separation of small molecules from industrial process streams for a range of industries. The $275,000 award to Avanpore LLC, a for-profit limited liability company located in Woburn, MA, will run from October 1, 2024 to March 31, 2025. The project aims to create functionalized...

The National Oceanic and Atmospheric Administration (NOAA) awarded a $524,307 SBIR (CFDA 11.021) Project Grant to Pure Spun Innovations to develop an innovative water purification technology using NASA-validated vapor compression distillation. The project aims to create a scalable, energy-efficient system to substantially reduce or eliminate per- and polyfluoroalkyl substances (PFAS) from wastewater effluent, preventing further contamination of water resources. The proposed solution uses a novel...

This $255,982 National Science Foundation project grant supports the development of sustainable, cost-effective viral clearance membranes by Filtravate, Inc. to enable efficient monoclonal antibody processing. The NSF Technology, Innovation, and Partnerships program seeks technologies leading to breakthrough solutions for national challenges. Specifically, Filtravate will develop a virus filtration membrane using a synthesis process that is more sustainable and affordable than conventional...

This $902,504 cooperative agreement from the National Science Foundation Division of Industrial Innovation under the Engineering program (CFDA 47.041) supports the development of a scalable downstream purification process for gene therapy vectors by Isolere Bio, Inc. of Durham, North Carolina. The non-chromatographic method seeks to address current inefficiencies that lead to single digit yields by utilizing a polypeptide-based reagent combining affinity capture with phase separation and...

This $275,000 Small Business Innovation Research (SBIR) Phase I award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program supports the development of a label-free, high-resolution, high-throughput protein screening platform called Vibrational Spectroscopy with Metasurface Optics (VISMO). The technology aims to enable simultaneous, minute-scale measurement of millions of protein samples, which would dramatically improve the lengthy and costly cycles...

Zaiput Flow Technologies LLC received a $275,000 Project Grant award from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop an innovative, continuous crystallization device for pharmaceutical manufacturing. The goal is to improve the purification process of active pharmaceutical ingredients, which is a critical step used in over 90% of pharmaceutical production. The novel device aims to address scalability, cost, and...

New Horizon Biotech Inc. received a $256,000 National Science Foundation SBIR Phase I Project Grant to determine performance characteristics during cultivation of living organisms in a novel single-use horizontal modular and pressurizable microbial fermentor. The funding period is from February 15, 2021 through May 31, 2023 under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084). This program seeks to advance science, engineering, and technology innovations to address...

Partillion Bioscience Corp. was awarded a $659,037 Project Grant from the National Institutes of Health's National Institute of General Medical Sciences to develop reagent products enabling high-throughput screening and selection of single cells based on secreted bio-products. Under the Biomedical Research and Research Training program (CFDA 93.859), Partillion plans to transition its lab-on-a-particle technology—highlighted as a 2020 SLAS Innovation Award winner—into the first reagent product...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) totaling $599,409 supports the development of a novel protein expression platform by Opera Bioscience, Inc. to produce cost-effective recombinant proteins and growth factors for therapeutic applications. The platform leverages the bacterial type III secretion system to transport proteins directly from the cytoplasm to the extracellular space,...