Project Grant 1951076

This SBIR Phase I award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $275,000 to Caravel Bio, Inc. to develop a novel synthetic biology platform for high-throughput directed evolution of spore-displayed enzymes. The project aims to create customizable enzyme solutions for industrial biocatalyst applications by improving key properties like enzyme activity, stability, and loading density. The technology uses a...

This $275,000 Small Business Innovation Research (SBIR) Phase I award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program supports the development of a label-free, high-resolution, high-throughput protein screening platform called Vibrational Spectroscopy with Metasurface Optics (VISMO). The technology aims to enable simultaneous, minute-scale measurement of millions of protein samples, which would dramatically improve the lengthy and costly cycles...

Under a $293,308 Project Grant awarded by the National Science Foundation (NSF) Division of Chemistry through the Mathematical and Physical Sciences program (CFDA 47.049), Purdue University is conducting research to develop new chiral catalysts for enantioselective photoredox-catalyzed carbon-carbon bond-forming reactions. The project aims to design efficient photochemical reactions to synthesize specific enantiomers of chiral organic molecules, which have important applications in...

This Project Grant award of $283,805 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) supports the development of a novel cell-free, high-throughput platform to expedite the engineering of enzymes for biocatalytic "bioclick" reactions. The project, led by Invizyne Technologies, Inc., a self-certified small disadvantaged business in Monrovia, California, aims to integrate cell-free protein synthesis...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $274,918 to Cascade Biocatalysts Inc. will fund research and development to demonstrate the commercial feasibility and scalability of a patent-pending approach for stabilizing enzymes through engineered polymer-enzyme interactions. The goal is to enable environmentally sustainable, low-carbon chemical manufacturing processes that utilize enzymes as catalysts, which can decrease...

New Iridium, Inc. received a $1 million cooperative agreement award from the National Science Foundation under the Technology, Innovation, and Partnerships program (CFDA 47.084) to develop light-driven chemical processes for converting captured carbon dioxide into terephthalic acid. Specifically, the company will work to mature photocatalysis technology to activate carbon dioxide for production of the commodity chemical at bench and engineering scales. Through high-throughput experimentation and...

This three-year, $544,758 project grant from the National Science Foundation Division of Chemistry supports the development of new optical sensing methodologies to accelerate and broaden chiral compound analysis at Georgetown University. The university's Chemistry Department will introduce widely applicable small-molecule probes, novel molecular recognition strategies, artificial intelligence tools, and automated high-throughput experimentation technology. This will help overcome current...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) award provides $274,727 to Weka Biosciences LLC, a woman-owned small business, to develop a novel microbial process for creating a synthetic sugar polymer for use in chiral chromatography. The goal is to produce a more reliable and efficient polymer material to enhance the precision of drug manufacturing and contribute to safer, more effective medications. The 12-month project will focus on...

This Project Grant award, totaling $1,000,000.00, was provided by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084). The award will support the development of a mid-infrared imager for analyzing chiral drug-tissue interactions. The key objective of this research project is to enhance the understanding of how chiral drugs, which have specific three-dimensional molecular structures, interact with different tissues within the...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $1,793,116 to the University of Wisconsin System, specifically the University of Wisconsin-Madison, to develop innovative synthetic methods and platforms for rapidly producing stereochemically complex molecules with high sp3 content. The research aims to leverage underexplored reactive intermediates, such as...