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All Federal Grant Awards
Project Grant 1938527
Award Date
3/1/20
Completion Date
4/30/23
Dollars Obligated
$225K
Overview
Activity
3
Transactions
3
Subawards
Similar Awards
Federal Agency
National Science Foundation
Awardee
Seetrue Technology, LLC (LJ1ZKX7C8SL5)
Federal Grant Program
47.084
Assistance Type
Project Grant
Place of Performance
Halethorpe, MD 21227, USA
Update #1
Update #2
STTR PHASE I: THREE-DIMENSIONAL PRINTING OF MICRO-CAPILLARY NEEDLE VIA DIRECT LASER WRITING
Posted 3/2/20
5
1
Mod #
Description
ReasonForModification
Federal Obligation
Date
Not listed
STTR PHASE I: THREE-DIMENSIONAL PRINTING OF MICRO-CAPILLARY NEEDLE VIA DIRECT LASER WRITING -THE BROADER/COMMERCIAL IMPACT OF THIS SBIR PHASE I PROJECT LEVERAGES RECENT ADVANCES IN ADDITIVE MANUFACTURING TO SOLVE KEY TECHNICAL HURDLES AND DESIGN DEFICITS OF CURRENT INDUSTRY STANDARD MICROCAPILLARY NEEDLES. MICROINJECTION IS A WELL-ESTABLISHED ENGINEERING TECHNIQUE AND WIDELY USED IN RESEARCH AND MEDICAL APPLICATIONS SUCH AS DRUG DISCOVERY AND DEVELOPMENT, FERTILITY TREATMENTS, AND GENETICS RESEARCH. THE PROPOSED TECHNOLOGY WILL USE ADDITIVE (3D) MANUFACTURING TECHNIQUES FOR A NEW MICROCAPILLARY NEEDLE TO IMPROVE THE QUALITY, REPRODUCIBILITY, RIGOR, AND EFFICACY OF THIS METHOD FOR A MARKET ESTIMATED AT $290 M. THIS TECHNOLOGY WILL POSITIVELY IMPACT LIFE SCIENCES RESEARCH AND MEDICAL APPLICATIONS. THE PROPOSED PROJECT WILL UTILIZE STATE-OF-THE-ART SUBMICRON-SCALE ADDITIVE MANUFACTURING TECHNOLOGIES TO REVOLUTIONIZE MICROINJECTION EFFICACY VIA SUBSTANTIVE VERSATILITY IN THE DESIGN AND FABRICATION OF THE NEEDLE-TIP. IN PARTICULAR, TWO-PHOTON DIRECT LASER WRITING (DLW) ? WHEREIN A FOCUSED LASER IS PRECISELY POSITIONED WITHIN A BIOCOMPATIBLE PHOTO MATERIAL TO PRODUCE 3D STRUCTURES COMPRISING CURED MATERIAL ? PROVIDES AN UNPARALLELED LEVEL OF GEOMETRIC CONTROL WITH FEATURE RESOLUTIONS ON THE ORDER OF 100 NM. THESE CAPABILITIES ENABLE NEW FLEXIBILITY IN RE-ARCHITECTING OF THE MICRONEEDLE TIP. IN ADDITION, DUE TO RECENT ENHANCEMENTS IN PRINTING SPEED, DLW-BASED APPLICATIONS CAN NOW SHIFT FROM NICHE DEMONSTRATIONS IN THE LABORATORY TO FULLY FUNCTIONAL COMMERCIAL PRODUCTS THAT SUPPORT RAPID OPERATION AT SCALE. THE PROJECT PROPOSES MULTIPLE CONFIGURATIONS FOR EACH PROPOSED DESIGN CHANGE WITH RESPECT TO KEY PERFORMANCE METRICS: THE ANTI-CLOGGING EFFICACY AND FABRICATION REPEATABILITY. THIS PROJECT WILL: ESTABLISH AND CHARACTERIZE NOVEL MANUFACTURING PROTOCOLS, SIMULATE EXPECTED CHARACTERISTICS, EXPERIMENTALLY ASSESS (BOTH IN THE LAB AND IN VITRO USING THE ZEBRAFISH EMBRYO) THE QUANTITATIVE EFFICACY OF THESE DISTINCT AND NOVEL ARCHITECTURES, AND QUALITATIVELY EVALUATE THE USER'S EXPERIENCE. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.
$0
3/6/23
Not listed
STTR PHASE I: THREE-DIMENSIONAL PRINTING OF MICRO-CAPILLARY NEEDLE VIA DIRECT LASER WRITING
$0
12/21/21
Not listed
STTR PHASE I: THREE-DIMENSIONAL PRINTING OF MICRO-CAPILLARY NEEDLE VIA DIRECT LASER WRITING
$225.0k
3/2/20