Project Grant 1843623

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Phase I Small Business Innovation Research (SBIR) project grant, awarded to Selight, LLC, aims to develop a rapid diagnostic instrument for assessing the health and viability of chimeric antigen receptor (CAR) T cells prior to their use in cancer immunotherapy. The $304,733 award, effective July 1, 2025 through June 30, 2026, will fund the design, engineering, and prototyping of an optical metabolic...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) is focused on developing a scalable manufacturing process for producing designer red blood cells (RBCs) derived from induced pluripotent stem cells (iPSCs). The $568,264 award to SAFI Biotherapeutics Inc., a pre-clinical blood cell therapy company, aims to optimize the iPSC-derived RBC (iRBC) production and validate the performance of different iRBC...

Partillion Bioscience Corp. was awarded a $659,037 Project Grant from the National Institutes of Health's National Institute of General Medical Sciences to develop reagent products enabling high-throughput screening and selection of single cells based on secreted bio-products. Under the Biomedical Research and Research Training program (CFDA 93.859), Partillion plans to transition its lab-on-a-particle technology—highlighted as a 2020 SLAS Innovation Award winner—into the first reagent product...

This National Science Foundation (NSF) Project Grant award under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program provides $305,000 to Cellecho, Inc. to develop a microchip-based technology that leverages sound waves and electric fields to manipulate cells and sequentially deliver customizable combinations of genetic materials. The goal is to make advanced cell engineering more accessible and streamlined, accelerating discoveries in cell and gene therapy, biotechnology,...

The National Cancer Institute has awarded a $275,627 Project Grant to Link Biosystems Inc., a self-certified small disadvantaged business and for-profit organization, to develop the ONXPANSION bioreactor workflow. This workflow aims to enable efficient expansion of patient-derived induced pluripotent stem cells into clinically relevant cell doses to support autologous cell therapy applications. The grant supports efforts to de-risk the utility of Link Biosystems' bioreactor technology for...

Rattan Life Science Inc. received a $275,000 Project Grant award from the National Science Foundation under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop a platform for generating induced pluripotent stem cell-derived naïve CD4+ and CD8+ T cells with fidelity, reproducibility and scalability. The platform employs proprietary induced thymic epithelial cells to provide biologically relevant thymic positive selection signals during T cell differentiation,...

This $295,924 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) aims to develop and demonstrate a high-yield microfluidic device for the enrichment and capture of CD3+ T cells. This device is intended to improve the manufacturing of autologous and allogenic engineered cell therapies such as CAR-T, which currently have time-consuming and costly production processes. The key objectives are to (1)...

This $125,805 Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) aims to develop new cell sorting technologies that can identify and separate cells based on changes in the activity of naturally occurring light-emitting molecules like NAD(P)H. The goal is to enable label-free, rapid identification and purification of cell populations, with a focus on stem cells and their functional subsets. The research will create a single cell deposition module to...

The National Science Foundation awarded Cytorecovery Inc. a $255,986 Small Business Technology Transfer Phase I Project Grant under the Engineering program (CFDA 47.041) on March 15, 2021. The grant funded the development of on-chip integration of sample preparation and monitoring capabilities with dielectrophoretic cell isolation techniques. The Engineering program seeks to improve quality of life and economic strength by fostering innovation and excellence in engineering research. This award...

This $500,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences, under the Biological Sciences federal grant program (CFDA 47.074), will support research to develop an end-to-end continuous manufacturing process for cell therapies using robotics and microfluidic technologies. The Georgia Tech Research Corporation will receive funding to create a more integrated workflow based on microfluidic device-enabled genetic engineering, cell expansion, and...