Project Grant 1764352

The National Science Foundation Division of Chemistry awarded a $374,888 Project Grant to Texas A&M University-Corpus Christi to support research examining the effect of templating agents on the size, shape, and chiral recognition of bifurcated amino acid-based amphiphilic molecular assemblies. The goal is to understand factors controlling self-assembly and interactions with biologically relevant molecules of these novel branched surfactant systems. A collaboration between Texas A&M...

This three-year, $544,758 project grant from the National Science Foundation Division of Chemistry supports the development of new optical sensing methodologies to accelerate and broaden chiral compound analysis at Georgetown University. The university's Chemistry Department will introduce widely applicable small-molecule probes, novel molecular recognition strategies, artificial intelligence tools, and automated high-throughput experimentation technology. This will help overcome current...

This Project Grant award from the National Science Foundation (NSF) Directorate for Mathematical and Physical Sciences (CFDA 47.049) provides $124,862 to the University of Rhode Island (URI) Research Office Division to advance the applications of organic photocatalysts in organic synthesis. Professor Lorenzo Mosca and his research group at URI will design and study fluorous (fluorine-containing) photocatalysts with improved resistance to photodegradation and enhanced recovery, enabling more...

This National Science Foundation (NSF) Division of Chemistry award provides $760,000 over 4 years to support an interdisciplinary research project led by Professors Colin Nuckolls and Xavier Roy of Columbia University. The project aims to explore the development of a new class of macromolecular materials that combine electronic and chiral properties, with the goal of understanding how chirality can be used to control spin-selective electron transport. This research will integrate advanced design...

This $369,285 National Science Foundation Division of Chemistry Project Grant supports the development of novel nonaqueous solvents known as "water-like ionic liquids" for use in enzymatic carbon-carbon bond formation reactions. Principal investigators Dr. Hua Zhao of the University of Northern Colorado and Dr. Gary Baker of the University of Missouri-Columbia, along with collaborator Dr. Katie Mitchell-Koch of Wichita State University, are designing dual-functionalized ionic liquids...

This Project Grant award, provided by the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049), supports Professor Julie Pigza of the University of Southern Mississippi (USM) in investigating the use of chiral and achiral squaramide organocatalysts to deliver a masked acyl cyanide (MAC) reagent. The $478,216 award, active from August 1, 2025 through July 31, 2029, will enable an interdisciplinary research approach focused on organic synthesis,...

This $396,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop cutting-edge nanophotonic technologies for probing and manipulating molecular and cellular chirality. The research seeks to provide groundbreaking insights into the interplay between molecular and cellular chirality, and how they affect cellular functions and disease mechanisms. Key anticipated outcomes...

This $390,000 federal Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports research led by Professor Yong Guo and his team at Fairleigh Dickinson University (FDU) to develop a new methodology for quantitatively evaluating the retention mechanisms in hydrophilic interaction chromatography (HILIC). The goal is to better understand the complex separation principles behind HILIC, which is widely used in biomedical...

This $359,641 National Science Foundation project grant supports research at Stony Brook University to investigate spontaneous emulsification phenomena in microchannels. Specifically, the award will fund an integrated teaching and research program to study the influence of miscible solvents like alcohols on multiphase liquid-liquid flows and develop new predictive models. Using advanced microfluidic techniques, the researchers will systematically characterize interfacial phenomena leading to...

Yale University was awarded a $1,050,000 Project Grant from the National Science Foundation Division of Chemistry under the Mathematical and Physical Sciences program (CFDA 47.049) to conduct research probing the origins of intrinsic chiroptical response and the roles of extrinsic perturbations. The research will combine experimental measurements and theoretical analyses to study how atomic motions and surrounding solvent affect the chiroptical properties of molecules. Discoveries could have...