Project Grant 1747250

This $275,000 Small Business Innovation Research (SBIR) Phase I award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program supports the development of a label-free, high-resolution, high-throughput protein screening platform called Vibrational Spectroscopy with Metasurface Optics (VISMO). The technology aims to enable simultaneous, minute-scale measurement of millions of protein samples, which would dramatically improve the lengthy and costly cycles...

This $274,990 Small Business Innovation Research (SBIR) Phase I award from the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships) supports the development of a physics-based machine learning platform for predicting the crystal structure of small drug molecules. The technology aims to accelerate and reduce the cost of early-stage pharmaceutical research and development by computationally analyzing the crystal structure properties that determine key...

This SBIR Phase I award from the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $273,550 to Biocognon LLC for the development of a combinatorial platform to discover improved molecular recognition components for use in therapeutic and diagnostic antibodies. The project aims to utilize synthetic biology, next-generation DNA sequencing, and computational biology to efficiently generate and screen libraries of antibody...

This SBIR Phase I project, awarded by the National Science Foundation (NSF) under the NSF Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084), aims to develop a method to turn on cancer immunotherapies only at the site of disease. The $275,000 award will support Synsorybio, Inc., a for-profit organization, in creating protein switches that activate immunotherapies in response to disease signals, rather than indiscriminately throughout the body. This approach seeks to improve the...

This Project Grant award from the National Science Foundation (NSF) Computer and Information Science and Engineering (CISE) program (CFDA 47.070) provides $275,956 to the University of Massachusetts Lowell to develop an engineered cyber-physical system that combines advanced biological models with state-of-the-art artificial intelligence (AI) methods. The goal is to enable accurate, real-time prediction of patient responses to anti-cancer therapies, advancing the precision medicine paradigm...

The National Science Foundation (NSF) awarded a $275,000 SBIR Phase I grant under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program to Om Therapeutics Inc. in La Jolla, CA. The goal of this project is to enable the discovery of new medicines at an unprecedented rate by empowering researchers to launch drug discovery programs quickly and cost-effectively. The innovation involves the ability to screen billions of unique small molecules against the entire human proteome in a...

This SBIR Direct-to-Phase II federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $1,640,169 to Synvivia, Inc. for the period from December 15, 2024 to November 30, 2026. The funding supports the development and validation of Synvivia's platform for identifying cyclic peptides that can dramatically increase the yield and quality of adeno-associated virus (AAV) vectors...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859, the Biomedical Research and Research Training Program, provides $303,024 to Biocognon LLC to develop an innovative combinatorial nanobody discovery platform for G-protein coupled receptors (GPCRs). The key products and services to be delivered include: 1) Developing a robust 4-piece Golden Gate assembly system utilizing validated yeast secretion and display vectors to facilitate...

This $150,000 Project Grant awarded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) aims to develop a personalized, home-use system for noninvasive monitoring of drug levels. The key objectives are to: (1) create a personalized drug titration pharmacokinetic model; (2) develop electrochemistry assays for measuring anti-seizure drug levels in saliva;...

This SBIR Phase I grant, awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program, provides $305,000 to Novaurum Biosciences Incorporated to develop a novel mammalian cell-based nano-biological coating for implantable medical devices. The goal is to address the critical health and economic burden associated with implant-related infections by creating a biocompatible and antimicrobial coating that can inhibit biofilm formation and...