Project Grant 1746311

This $274,990 Small Business Innovation Research (SBIR) Phase I award from the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships) supports the development of a physics-based machine learning platform for predicting the crystal structure of small drug molecules. The technology aims to accelerate and reduce the cost of early-stage pharmaceutical research and development by computationally analyzing the crystal structure properties that determine key...

This $275,000 Small Business Innovation Research (SBIR) Phase I award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program supports the development of a label-free, high-resolution, high-throughput protein screening platform called Vibrational Spectroscopy with Metasurface Optics (VISMO). The technology aims to enable simultaneous, minute-scale measurement of millions of protein samples, which would dramatically improve the lengthy and costly cycles...

This SBIR Phase I award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $275,000 to Caravel Bio, Inc. to develop a novel synthetic biology platform for high-throughput directed evolution of spore-displayed enzymes. The project aims to create customizable enzyme solutions for industrial biocatalyst applications by improving key properties like enzyme activity, stability, and loading density. The technology uses a...

Under a $293,308 Project Grant awarded by the National Science Foundation (NSF) Division of Chemistry through the Mathematical and Physical Sciences program (CFDA 47.049), Purdue University is conducting research to develop new chiral catalysts for enantioselective photoredox-catalyzed carbon-carbon bond-forming reactions. The project aims to design efficient photochemical reactions to synthesize specific enantiomers of chiral organic molecules, which have important applications in...

This three-year, $544,758 project grant from the National Science Foundation Division of Chemistry supports the development of new optical sensing methodologies to accelerate and broaden chiral compound analysis at Georgetown University. The university's Chemistry Department will introduce widely applicable small-molecule probes, novel molecular recognition strategies, artificial intelligence tools, and automated high-throughput experimentation technology. This will help overcome current...

This $1,972,972 Project Grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research into novel synthetic methodologies for preparing complex bioactive molecules. Conducted by UC Berkeley from May 2025 through April 2030, the project focuses on discovering simplified synthetic disconnections and strategies to efficiently synthesize biologically important diterpenes from the plant families...

The U.S. National Science Foundation (NSF) awarded a $303,864 Phase I Small Business Innovation Research (SBIR) grant under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program to Core Biotherapeutics, Inc. (UEI N9FGZ15RQGJ4) located in Ladera Ranch, CA. The project aims to develop a platform for discovering therapeutic drug candidates that can modulate molecular networks driving diseases, with the potential to produce disease-modifying effects for neurodegenerative...

This Project Grant award from the National Science Foundation (NSF), under the Mathematical and Physical Sciences program (CFDA 47.049), supports research led by Professor Scott E. Denmark at the University of Illinois at Urbana-Champaign. The $800,000 award will fund a 4-year project to develop new catalytic methods for the stereoselective synthesis of pharmaceutically-relevant heterocyclic compounds. The research aims to use selenium-based catalysts to efficiently construct important ring...

This National Science Foundation Technology, Innovation, and Partnerships Project Grant of $256,000 will support the development of a novel mass spectrometer by Moires Instruments, LLC to identify molecular isomers and distinguish their conformational forms. The instrument uses high electric fields to manipulate neutral molecules based on their dipole moments, separating them by mass-to-dipole-moment ratio rather than conventional mass-to-charge ratio. This approach aims to reduce the...

This $575,000 project grant awarded by the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences program (CFDA 47.049) supports research at Emory University to develop practical methods for conducting synthetic organic transformations using low catalyst loadings. The goal is to create highly efficient catalysts, such as rhodium and ruthenium-based catalysts, that can be used in extremely low amounts to enable over 100,000 reaction cycles while...