Project Grant 1621065

This National Science Foundation Project Grant of $536,946 will support research at the University of California, San Diego from September 2022 through August 2025 under the Mathematical and Physical Sciences program (CFDA 47.049). The award will fund the development of rigorous scientific theories and powerful computational tools to model biomolecular interactions. Researchers will design advanced numerical methods to simulate drug and protein binding/unbinding kinetics, incorporating molecular...

This SBIR Phase I project, funded by a $305,000 award from the National Science Foundation's (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program, aims to develop a microchip-based technology for complex, multidimensional cell reprogramming. The project seeks to create a miniaturized liquid and cell handling system that leverages acoustic-electric micro-vortices to precisely and sequentially deliver genetic molecules, making advanced cell engineering more accessible across...

This $275,000 Small Business Innovation Research (SBIR) Phase I award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program supports the development of a label-free, high-resolution, high-throughput protein screening platform called Vibrational Spectroscopy with Metasurface Optics (VISMO). The technology aims to enable simultaneous, minute-scale measurement of millions of protein samples, which would dramatically improve the lengthy and costly cycles...

This award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $741,000 to the University of Chicago to develop a fast and accurate computational tool called UPSIDE for simulating the dynamics and structure of large membrane proteins involved in sensing environmental stimuli like force and heat. The research aims to enhance the understanding of how sensory membrane proteins in humans and animals function at the atomic level, which is crucial for addressing...

This $274,990 Small Business Innovation Research (SBIR) Phase I award from the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships) supports the development of a physics-based machine learning platform for predicting the crystal structure of small drug molecules. The technology aims to accelerate and reduce the cost of early-stage pharmaceutical research and development by computationally analyzing the crystal structure properties that determine key...

This Project Grant award of $300,000 from the National Science Foundation (NSF) Integrative Activities program (CFDA 47.083) supports the development and experimental validation of computational tools for simulation-guided design of DNA nanostructures and molecular systems. The project aims to integrate high-level and low-level computational models to enable more powerful and user-friendly multiscale modeling frameworks for DNA nanotechnology. Key objectives include parameterizing coarse-grained...

This STTR Phase I project, awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084), aims to revolutionize drug discovery by accelerating molecular dynamics simulations through advanced AI techniques. The $305,000 award, granted on July 15, 2025, with a completion date of June 30, 2026, will enable Giwotech Inc. to develop a robust neural network model capable of simulating protein systems up to 500 times faster than...

This $436,361 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative computational tools and algorithms to advance small-angle and wide-angle X-ray scattering (SWAXS) analysis for studying the structure and dynamics of biological macromolecules. The key objectives of this 5-year project include: 1) Improving the resolution of density reconstructions...

This SBIR Phase II Cooperative Agreement, awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084), provides $1,213,322 in funding to Lavo Life Sciences Inc. to develop a physics-based machine learning platform for predicting the crystal structure of small drug molecules. The objective is to accelerate the development and commercialization of new pharmaceutical products by optimizing drug product formulations and solid forms....

This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop state-of-the-art software tools capable of accurately modeling bound drug molecules in receptor structures from cryo-electron microscopy (cryo-EM) data with resolutions up to 5-6 Angstroms. The $217,941 award to Molecular Intelligence LLC, a small business, will run from September 1, 2025 to February 28, 2027. This...