Project Grant 1456224

This $275,000 Small Business Innovation Research (SBIR) Phase I award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program supports the development of a label-free, high-resolution, high-throughput protein screening platform called Vibrational Spectroscopy with Metasurface Optics (VISMO). The technology aims to enable simultaneous, minute-scale measurement of millions of protein samples, which would dramatically improve the lengthy and costly cycles...

Federal Grant Award Summary Primary Bioscience, Inc. received a $305,000 Small Business Technology Transfer (STTR) Phase I award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships program (CFDA 47.084) effective July 15, 2025, with a completion date of June 30, 2026. The company is developing an ultra-sensitive biosensor capable of single-molecule protein analysis and sequencing. The technology integrates a nanopatterned chip with a proprietary amino acid and...

This Project Grant award of $432,834 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) with a performance period from April 15, 2025 to March 31, 2028. The objective is to develop an enzyme-free, label-free quantitative microarray technology to accurately measure and quantify small nucleic acid targets such as microRNA in the attomolar range for applications like liquid biopsy. The research...

This National Science Foundation (NSF) Project Grant award for $380,074, awarded on September 1, 2024, aims to develop a platform for instrument-free, easy-to-interpret quantitative analysis of molecular biomarkers. The project will produce a general methodology adaptable to a range of molecular targets, including potential new agents. The key products to be delivered include: A "yes/no" output for quantitative measurement, enabled through stoichiometry and negative cooperativity-based...

Federal Grant Award Summary Newomics Inc. received a $1,000,000 Project Grant award from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025 through August 31, 2027. The Small Business Innovation Research (SBIR) Phase II project will further develop and commercialize the UniESI platform, an integrated imaging-mass spectrometry front-end system featuring M3 emitters and MEA chips designed to...

The National Cancer Institute (NCI) awarded Pacific Northwest National Laboratory (PNNL), a division of Battelle Memorial Institute, a $450,904 Project Grant under the Cancer Biology Research program (CFDA 93.396) to develop an innovative single-cell (phospho-)proteomics platform for analyzing the tumor microenvironment (TME). The three-year award, active from September 1, 2025 through August 31, 2028, funds the development of technology to address critical limitations in current single-cell...

Federal Project Grant Award Summary Vivid Bioinnovations, PBC (operating as Fluid Discovery, Inc.) received a $306,872 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) for the period August 1, 2025 through July 31, 2026. The award supports development of a commercial prototype for an ultrahigh-throughput biocatalyst evolution platform that combines precision nanoliter fluid handling, label-free...

Federal Grant Award Summary BrightSpec, Inc. received $1,194,805 in Phase II Small Business Innovation Research (SBIR) funding from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), awarded August 1, 2025, with completion targeted for July 31, 2027. The award supports development of a Molecular Rotational Resonance (MRR) Ratiometer—an advanced spectroscopic instrument designed to precisely quantify component abundances...

This National Science Foundation Project Grant of $255,261 awarded under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) will fund the development of optimized extraction and projection optics for ion point sources. Steam Instruments Inc. will demonstrate technology advances in imaging mass spectrometry through this Small Business Innovation Research Phase I project. Specifically, the company aims to markedly improve mass resolving power to separate key mass...

The National Science Foundation awarded Ionicscale LLC $256,000 under the Technology, Innovation, and Partnerships federal grant program to develop low-cost, portable mass spectrometers based on a chip-scale ion trap mass analyzer. The award aims to advance the company's technology for ubiquitous, high-specificity chemical analysis through a novel ion trap geometry that can be microfabricated at lower costs. This has the potential to bring mass spectrometry capabilities, which are currently...