Project Grant 1447944

This $274,990 Small Business Innovation Research (SBIR) Phase I award from the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships) supports the development of a physics-based machine learning platform for predicting the crystal structure of small drug molecules. The technology aims to accelerate and reduce the cost of early-stage pharmaceutical research and development by computationally analyzing the crystal structure properties that determine key...

This SBIR Phase I award from the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships) provides $304,972 to Particle4X, Inc. to develop a real-time, inline sensor system that integrates digital inline holography and deep learning to detect particulate matter and microbial contaminants during injectable drug manufacturing. The system aims to enable continuous quality monitoring, supporting the industry's shift from batch to continuous manufacturing. Key...

This SBIR Phase II Cooperative Agreement, awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084), provides $1,213,322 in funding to Lavo Life Sciences Inc. to develop a physics-based machine learning platform for predicting the crystal structure of small drug molecules. The objective is to accelerate the development and commercialization of new pharmaceutical products by optimizing drug product formulations and solid forms....

The National Science Foundation (NSF) has awarded a $305,000 SBIR Phase I project grant under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program to Plexymer, Inc. for the development of an AI-directed automation system to accelerate the bioformulation of antibody therapeutics. The project aims to enable the transformation of hospital-administered antibody infusions into self-administered at-home injections by pairing laboratory robotics with artificial intelligence to...

Nano Pharmasolutions, Inc. received a $275,961 Project Grant award from the National Science Foundation Division of Industrial Innovation under the Engineering federal grant program (CFDA 47.041). The grant funds the development of a novel nanoformulation drug delivery platform to address challenges associated with poorly soluble drugs. The goal is to improve drug solubility and bioavailability through innovative formulation approaches. The one-year project period runs from August 1, 2021...

This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) provides $463,746 to the University of Puerto Rico Medical Sciences Campus (UPR-MSC) to study an innovative continuous crystallizer concept. The objective is to develop robust, scalable, and miniaturized equipment for pharmaceutical manufacturing that can improve resilience to supply chain disruptions and better meet fluctuating market needs. The research seeks to advance continuous...

This SBIR Phase I project, funded by a $305,000 award from the National Science Foundation's (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program, aims to develop a microchip-based technology for complex, multidimensional cell reprogramming. The project seeks to create a miniaturized liquid and cell handling system that leverages acoustic-electric micro-vortices to precisely and sequentially deliver genetic molecules, making advanced cell engineering more accessible across...

This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $350,000 in funding to Cisterna Biologics, Inc. to develop a novel mRNA production and purification process. The key objectives are to: Optimize psychrophilic (cold-adapted) RNA polymerases and synthetic promoters to minimize contaminants in mRNA synthesis, improving safety and efficacy for therapeutic use. Implement...

This SBIR Phase I project, funded by the National Science Foundation's (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program, aims to develop hardware that enables the rapid and cost-effective synthesis of DNA-encoded libraries (DELs). The $294,932 award, granted to Femtofluidics Incorporated, will be used to build a device that can perform combinatorial chemistry on nanoliter to picoliter volume droplets using an electronic substrate, rather than traditional liquid-handling...

This Small Business Innovation Research (SBIR) Phase II Cooperative Agreement, awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program, focuses on refining and optimizing a temperature control and insulation system for storing and transporting temperature-sensitive medications, biologics, and other perishable components. The key innovation involves decoupling the thermoelectric coolers from the cooled payload to minimize energy...