Project Grant 1447207

This SBIR Phase I award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $275,000 to Caravel Bio, Inc. to develop a novel synthetic biology platform for high-throughput directed evolution of spore-displayed enzymes. The project aims to create customizable enzyme solutions for industrial biocatalyst applications by improving key properties like enzyme activity, stability, and loading density. The technology uses a...

This SBIR Phase I project, awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084), aims to develop a novel platform for accelerating the strain development process for precision fermentation. The $275,000 grant, awarded on January 15, 2025, will fund the recipient, Terraferma Foods, Inc., to leverage machine learning and experimental biology to enhance the industrial-scale production of animal proteins in yeast. The project...

Pumpkinseed Technologies Inc. received a $353,204 Phase I Small Business Innovation Research (SBIR) Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) on June 19, 2025, with completion targeted for April 30, 2026. The award funds development and proof-of-concept demonstration of Cell-MAPP (Cell Monitoring Against Presented Peptides), a novel technology that enables dynamic, real-time monitoring of individual T cell states during antigen...

This $275,000 Small Business Innovation Research (SBIR) Phase I award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program supports the development of a label-free, high-resolution, high-throughput protein screening platform called Vibrational Spectroscopy with Metasurface Optics (VISMO). The technology aims to enable simultaneous, minute-scale measurement of millions of protein samples, which would dramatically improve the lengthy and costly cycles...

Federal Project Grant Summary Krokos Bio Inc. received a $305,000 Project Grant from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084), with an award date of October 1, 2025 and completion deadline of March 31, 2027. The awardee will develop and deliver a scalable, domestically-based production method for saffron utilizing novel plant cell culture techniques. Specifically, the project involves cultivating Crocus sativus callus...

This Project Grant from the National Science Foundation (NSF) provides $274,999 to Robigo, Inc. for research under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084). The award will support development of a microbial biopesticide platform to precisely target and eliminate crop pathogens without harming beneficial microbes, pollinators, or humans. Leveraging synthetic biology, CRISPR, and data science, the company aims to engineer improvements increasing efficacy and viability...

The National Science Foundation awarded Opera Bioscience, Inc. $275,000 under the Technology, Innovation, and Partnerships program (CFDA 47.084) to develop a low-cost bacterial production platform for manufacturing high purity recombinant proteins and growth factors. The award period runs from June 15, 2023 through May 31, 2024. Opera Bioscience will utilize this funding to demonstrate the ability of its innovative protein production platform to solve challenges in traditionally costly and...

Federal Grant Award Summary Piccolo Biosystems, Inc. received a $295,861 Phase I Small Business Innovation Research (SBIR) grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2026. In collaboration with scientists at the University of Washington, Piccolo will develop and validate an innovative ultra-small scale assay platform for measuring enzyme...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $274,956 to Gulf Spore LLC (doing business as Chitovate) provides funding to develop an edible mushroom-derived chitosan coating to extend the shelf life of fresh fruits and vegetables. The project aims to create a sustainable, antimicrobial, and gas barrier coating alternative to reduce the $1 trillion in annual global food waste. Key objectives include demonstrating the...

The federal Project Grant award of $283,805 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of a novel cell-free, high-throughput platform to expedite the engineering of enzymes for biocatalytic "BioClick" reactions. The project, undertaken by Invizyne Technologies, Inc., a small disadvantaged business in Monrovia, CA, focuses on establishing an efficient cell-free protein...