Project Grant 0611376

This $275,000 Small Business Technology Transfer (STTR) Phase I grant from the National Science Foundation (CFDA 47.084 - NSF Technology, Innovation, and Partnerships program) was awarded to Oncoblaze LLC to develop a novel device for targeted delivery of chemotherapy agents to tissue surrounding surgically removed tumors. The project aims to address the issue of tumor recurrence after cancer surgery, which affects 30-40% of patients for certain cancers. The device uses an infrared laser to heat...

Starlight Cardiovascular, Inc. was awarded a $1,477,713 Project Grant from the National Heart, Lung, and Blood Institute's Cardiovascular Diseases Research program to develop the first FDA-approved stent designed specifically for ductus arteriosus. The ductus arteriosus is a natural blood vessel that remains open in infants born with certain congenital heart defects; currently there are no stents approved for this use, forcing clinicians to repurpose adult coronary stents which have a high 47%...

This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to develop and test a drug-eluting chest tube to locally manage the pain associated with its use in cardiothoracic surgeries. The $275,752 award supports two key objectives: 1) completing GMP/GLP studies on the drug release kinetics, stability, and manufacturing of the drug-releasing chest tube; and 2) evaluating the mechanical...

Precision Theranostics Inc. was awarded a $256,000 Small Business Innovation Research Phase I Project Grant by the National Science Foundation Division of Industrial Innovation. The grant supports the development of a lung health diagnostic test for chronic obstructive pulmonary disease and prognosis-based early intervention from May 1, 2021 to April 30, 2022. The grant falls under the National Science Foundation's Engineering program (CFDA 47.041), which seeks to improve quality of life and...

This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), is supporting the development of novel minimally invasive catheter-based devices for endovascular filtration. The goal is to remove chemotherapy drugs from the blood in order to reduce systemic toxicity during locoregional infusion therapy. The $670,440 award, granted on May 21,...

This Project Grant award, valued at $305,000.00 and provided by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program, supports the development and commercialization of a novel light-activatable nanoplatform for the targeted delivery of photodynamic therapy (PDT) and chemotherapy to treat peritoneal metastasis. The nanoplatform is designed to selectively eliminate cancer cells that could not be removed by surgery, with the goal of...

This Project Grant award from the National Science Foundation's (NSF) Integrative Activities program (CFDA 47.083) provides $500,000 to Alabama State University to design and develop an affordable, non-invasive point-of-care device for early diagnosis of lung cancer using a functionalized carbon dot biosensor. The key objectives are to: (1) synthesize and characterize the carbon dot-based biosensor functionalized with anti-CYFRA 21-1 antibodies, (2) assess the binding efficiency of the biosensor...

This federal Project Grant award of $374,095 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), aims to develop a device that uses an infrared laser to enable local delivery of a high dose of chemotherapy to the surgical cavity after tumor resection. The technology employs thermosensitive liposomal nanoparticles encapsulating chemotherapy agents that...

This National Science Foundation (NSF) Small Business Technology Transfer (STTR) Phase I project aims to develop a novel, minimally invasive, bioabsorbable, steroid-eluting suture and surgical implant procedure to improve outcomes for 6 million patients suffering from rhinitis under the care of otolaryngologists. The $255,045 award, granted on September 15, 2023 under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program, will fund the formulation of dissolvable polymers,...

This SBIR Phase I project, awarded by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program, is focused on the development of a novel mammalian cell-based nano-biological coating for implantable medical devices. The goal is to address the critical health and economic burden associated with implant-related infections by reducing or eliminating them through the use of this biocompatible and antimicrobial nano-biological coating. The $305,000...