Formula Grant P425F203088

The National Academy of Sciences was awarded a $199,912.00 Project Grant by the Department of the Navy Secretary of the Navy Office of Naval Research on August 1, 2023 under the Basic and Applied Scientific Research federal grant program (CFDA 12.300). The purpose of this one-year grant is to convene a workshop to identify emerging science and technology that can address naval undersea medicine needs. The National Academy of Sciences has extensive experience providing expert convening,...

This Project Grant award of $804,690 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants (CFDA 93.242) program aims to determine the relationship between N-acetyl-aspartyl-glutamate (NAAG) levels and memory deficits in schizophrenia patients in mid- to late-life. The funded research will measure NAAG levels using magnetic resonance spectroscopy and correlate them with declarative and working memory performance, as well as neural activity during memory...

This Project Grant award from the National Science Foundation (NSF) Division of Chemistry aims to develop a new class of rechargeable battery that pairs sodium metal with nitrogen oxide (NOx) gases. The $300,000 award made under the NSF's Mathematical and Physical Sciences (CFDA 47.049) program supports research at The Ohio State University to establish the fundamental (electro)chemistry of these Na-NOx batteries, improve their stability, and design flow cell prototypes. Key objectives include...

This is a Cooperative Agreement award from the National Institute on Aging (NIA), under the federal Aging Research grant program (CFDA 93.866), totaling $1,001,704 with a project period from August 2024 to July 2029. The award is to The Trustees of the University of Pennsylvania to conduct research aimed at developing and standardizing methods for analyzing nicotinamide adenine dinucleotide (NAD) and its metabolites in blood, serum, urine, and tissues. The key objectives are to: 1) establish...

This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $1,434,495 to Neuronasal Inc. to develop a novel intranasal (IN) nose-to-brain (N2B) treatment option for Parkinson's disease (PD) using the antioxidant N-acetylcysteine (NAC). The primary objectives are to: 1) establish the regional and temporal bioavailability profile of 50 mg/kg IV NAC in PD patients, 2) compare the bioavailability and safety of 200 mg and 400 mg IN N2B NAC versus the IV...

The National Oceanic and Atmospheric Administration (NOAA) is providing a 2-year, $250,000 Cooperative Agreement award under the Chesapeake Bay Studies program (CFDA 11.457) to the North American Association for Environmental Education (NAAEE). The purpose of this award is to establish and facilitate a regional community of practice for systemic environmental literacy and climate change education initiatives targeting school district administrators in the Mid-Atlantic region. The primary...

Novelmed Therapeutics, Inc. was awarded a $900,000 Project Grant from the National Institutes of Health's National Institute on Aging to develop a selective inhibitor of the alternative pathway of complement as a treatment for Neuromyelitis Optica Spectrum Disorder. Under the grant, Novelmed will conduct preclinical studies to evaluate its lead drug candidate NM5072, including in vitro and ex vivo assays to confirm the drug's mechanism of action and selective inhibition of the alternative...

The National Institute on Aging (NIA) awarded a $295,000 Project Grant (CFDA 93.866 - Aging Research) to Florida International University to develop biotherapeutic nanogels for the treatment of Alzheimer's disease. The goal is to create a novel nanogel system that can effectively cross the blood-brain barrier, inhibit amyloid-beta aggregation, and reduce oxidative stress and neuroinflammation associated with Alzheimer's. The project will focus on improving the nanogel formulation for enhanced...

This Project Grant award from the National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), aims to investigate the therapeutic potential of activating the niacin receptor HCAR2 to mitigate tau pathology in preclinical models of tauopathies, which are a group of neurodegenerative diseases including Alzheimer's disease and frontotemporal lobar degeneration. The $560,636 award to the Trustees of Indiana University, doing business as Indiana University...

The National Institute on Aging (NIA) awarded a $949,062 Project Grant (CFDA 93.866) to Somatoceutics LLC to develop a non-toxic, peptide-based nanomaterial (SMC-101 nanotubes) for delivering drugs across the blood-brain barrier to treat Alzheimer's disease and other dementias. The objectives are to optimize the nanotubes for drug-loading and transcytosis across a blood-brain barrier model in vitro, and then evaluate their toxicity and ability to deliver the drug galantamine to the central...