Center for multi-scale multi-omic human and non-human primate brain atlas
Active Cooperative Agreement Awarded Last action
- Award ID
- UM1MH134812
- Recipient
-
Massachusetts Institute Of Technology UEI E2NYLCDML6V1
- Awarding agency
-
National Institute of Mental Health
National Institutes of Health, Department of Health and Human Services
- Obligated
- $21,714,815
Award facts
- Assistance listing
- 93.242 Mental Health Research Grants
- Completion date 28% complete
- Place of performance
- Cambridge, MA 02139, USA
Award details come from USAspending.gov.
Description
- Abstract
- A detailed understanding of the functional, anatomical and molecular architectures of brain cells and their brain-wide organization is essential for interrogating normal human brain function and disease states. Extensive efforts have been made toward mapping brain cells through various approaches, resulting in invaluable databases that are yielding new insights. However, we still lack comprehensive human brain atlases that capture multi-level properties of individual cells while adequately representing human demographic diversity and individual variability. The goal of this proposal is to create fully integrated three-dimensional (3D) human and non-human primate (NHP) brain cell atlases at subcellular resolution by simultaneously mapping brain-wide function, structure, and high-dimensional features (e.g., proteomic, transcriptomic, spatial, morphological, microenvironment and nanoscopic information) of cells acquired from the same whole brains with complete coverage of all brain regions. Our team will accomplish this by seamlessly integrating multimodal data from state-of-the-art functional (for NHP brains), structural, diffusion MRI, and multiscale 3D proteomic/transcriptomic imaging technologies. Using the scalable technology pipelines, we will perform proteomic and transcriptomic imaging of (1) human brains acquired from a large number of demographically representative donors and (2) functionally characterized non-human primate brains. The proposed work will create the most comprehensive 3D human and NHP brain atlases to date, with unprecedented resolution and completeness. The atlases will establish inter-species homologies essential for the translation of insights derived from animal models to humans, and aid in identifying the cellular and molecular underpinnings of human cognition and susceptibility to disease. Additionally, the unprecedented, multiscale multi-omic datasets acquired from a large number of demographically representative human donors will enable population level inter-individual variation study and allow baseline characterization of cellular and subcellular features, providing an immediately useful reference frame for the research community to study disease-specific changes in cell composition, spatial distribution, and subcellular architectures. Finally, our team will work closely with existing bican centers to maximize synergy and utilization of scarce brain materials and enable true multimodal data integration.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $9,983,241 | |
| Original award | $11,731,574 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| President And Fellows Of Harvard College | $2,481,133 | |
| University Of Washington | $476,160 | |
| The Rockefeller University | $320,270 | |
| Lifecanvas Technologies Inc. | $2,146,907 | |
| The General Hospital Corporation | $478,473 | |
| Icahn School Of Medicine At Mount Sinai | $239,669 | |
| Addgene Inc. | $465,019 | |
| Allen Institute | $138,685 |
Quick answers
Who received award UM1MH134812?
UM1MH134812 was awarded to Massachusetts Institute Of Technology by National Institute of Mental Health (National Institutes of Health) on June 1, 2025.
How much is award UM1MH134812 worth?
$21,714,815 has been obligated on UM1MH134812.
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