Center for multiomic human brain cell atlas

Active Cooperative Agreement Awarded Last action

Award ID
UM1MH130994
Recipient
Awarding agency
Obligated
$186,684,014

Award facts

Assistance listing
93.242 Mental Health Research Grants
Completion date 86% complete
Place of performance
La Jolla, CA 92037, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Understanding cell identities and their spatial distributions throughout different regions of the human brain is a fundamental step when trying to integrate physiological, behavioral, neurochemical and molecular data. At present, although major categories of the cell-types present in the human brain have been defined molecularly, the different subtypes within these categories along with their locations are far from understood. Gene expression drives cell programs and states that underlie distinct brain functions. Open chromatin and modified histones mark gene-regulatory elements that control cell type-specific gene expression patterns. Cytosine DNA methylation (MC) is a stable epigenomic signature that persists in post-mitotic cells throughout their lifetime, defining their cellular identity. Single-cell gene expression, open chromatin profiles and DNA methylation assays have been successfully used to identify distinct cell types in an unbiased fashion in heterogeneous tissues including the human brain. This UM1 proposal builds on our earlier successes in mouse brain mapping to produce detailed single-cell multimomic and spatial cell maps at the single-cell level across 100 anatomically defined regions in the human brain. Profiling human brain samples will permit the discovery of unique gene expression patterns for each molecularly-defined cell type, identify their spatial organization, and their specific non-coding DNA regulatory regions. Multi-modal integration between epigenomic and transcriptomic signatures will allow the identification of new cell types and unique cell-type markers that will rapidly be made available to the entire community. This UM1 project will also provide new tools for genetic access of previously inaccessible brain regions as well as facilitate the functional analysis of genetic variants associated with neuropsychiatric and neurological disorders.

Transactions

Action Obligated Date
Amendment -$1,956,386
Amendment $19,563,871
Amendment $19,563,871
Amendment $0
Amendment $0
Amendment $0
Amendment $17,644,498
Amendment $17,644,498
Amendment $0
Amendment $0
Amendment $17,683,580
Amendment $17,683,580
Amendment $0
Amendment $14,108,251
Amendment $14,108,251
Amendment $0
Amendment $0
Amendment $0
Amendment $25,320,000
Original award $25,320,000
Show all 20

Subawards

Subrecipient Amount Awarded
University Of California Irvine Center for Multiomic Human Brain Cell Atlas $8,596,619
The Washington University $3,957,285
New York Genome Center, Inc. Dr. Ren’s group at New York Genome Center will carry out research activities related to the Specific Aims 2 and 3. Specifically, his lab will perform QC and… $1,367,556
The Washington University Center for Multiomic Human Brain Cell Atlas $3,196,887
University Of California, San Diego $21,130,893
Children's Hospital Of Orange County Recruitment, enrollment and execution of study for brain samples from donors. $238,004
University Of California, San Diego Center for Multiomic Human Brain Cell Atlas $5,678,497
University Of California, San Diego $1,800,260
University Of California Irvine $577,095
University Of California Irvine $1,767,972

Quick answers

Who received award UM1MH130994?

UM1MH130994 was awarded to The Salk Institute For Biological Studies. San Diego. California by National Institute of Mental Health (National Institutes of Health) on September 1, 2022.

How much is award UM1MH130994 worth?

$186,684,014 has been obligated on UM1MH130994.

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