Healthy hearts/ corazones saludables: partnership to promote cardiovascular health in hispanic and non-hispanic mothers and children in US home visiting programs

Active Cooperative Agreement Awarded Last action

Award ID
UH3HL163508
Recipient
Awarding agency
Obligated
$187,500

Award facts

Completion date 62% complete
Funding agency
National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health, Department of Health and Human Services
Place of performance
San Luis Obispo, CA 93407, USA

Award details come from USAspending.gov.

Description

Abstract
Cardiovascular disease (CVD) is the leading cause of death in US women, accounting for approximately one of every three female deaths. Obesity is arguably the strongest modifiable target for interventions to prevent CVD and is linked with nearly every other major CVD risk factor, including hypertension, elevated glucose, high cholesterol, poor diet, and physical inactivity. Infants of mothers with obesity are also at increased risk for future obesity and CVD. Our team has developed an empirically validated lifestyle intervention that is remotely delivered and highly successful in reducing body weight and improving CVH in hispanic and non-hispanic women and children during pregnancy and postpartum. IT is now critical to study ways to disseminate this empirically-validated program. Evidence based home visiting programs (ebhv), which support families from the prenatal period through infancy and early childhood, are an ideal setting to promote CVH, however these programs were not designed with an explicit focus on the prevention of obesity and other CVD risk factors. The proposed research will test the effectiveness of our pre- and postnatal lifestyle intervention as an enhancement to ebhv to promote maternal and child CVH. During an initial 2-year UG3 phase, we will: 1) modify our pre- and postnatal intervention to focus on CVH within ebhv; 2) work with our ebhv partners to integrate CVH messages and develop their related skills; 3) strengthen partnerships between healthcare providers and ebhv to increase referrals, retention, and improve CVH, and 4) contribute to the development of a high-impact study design for the subsequent UH3 phase involving a multi-cohort protocol, harmonized interventions, measures and resources. For the subsequent UH3 phase, we propose a hybrid type 1 effectiveness-implementation trial in which we recruit 550 perinatal women who will be randomized to receive ebhv alone or ebhv enhanced with our lifestyle intervention to promote CVH. Our primary hypothesis is that, over an average of 36 months, ebhv+CVH (VS. Ebhv alone) will result in more favorable maternal and child levels of the life's simple 7 indicators. We will also examine key intervention moderators, focusing on social determinants of health, and mediators, including changes in the home environment, social support, CVH behaviors, and program adherence. Using the RE-aim framework, we will determine reach, effectiveness, adoption, implementation, and maintenance of ebhv+CVH VS. Ebhv alone. Other goals are to empower and reduce burnout among home visitors; develop skills of early-stage investigators, and propose innovative ancillary studies to enhance the scientific contributions. Our team is exceptionally well positioned for this research and includes established investigators with decades of experience conducting NIH funded research, outstanding early stage investigators, and ebhv sites from central california and rhode island.

Transactions

Action Obligated Date
Amendment $62,500
Amendment $62,500
Original award $62,500

Subawards

Subrecipient Amount Awarded
Rhode Island Hospital PI is an Assistant Professor of Pediatrics at the Warren Alpert Medical School of Brown University and an attending physician at Hasbro Children’s Hospital.… $63,248
Emma Pendleton Bradley Hospital Dr. Parade is MPI of the current proposal. She will work closely with Drs. Phelan and Wing, and be responsible for overall study design, execution, and… $282,868
The Miriam Hospital Working with Cal Poly, The Miriam Hospital site will be responsible for half of the participants recruited at this Clinical Center in the ENRICH trial. We… $953,122

Quick answers

Who received award UH3HL163508?

UH3HL163508 was awarded to CAL Poly Corporation by National Heart Lung and Blood Institute (National Institutes of Health) on May 5, 2022.

How much is award UH3HL163508 worth?

$187,500 has been obligated on UH3HL163508.

Which agency awarded UH3HL163508?

National Heart Lung and Blood Institute (National Institutes of Health) awarded UH3HL163508, with funding from National Institute of Diabetes and Digestive and Kidney Diseases (National Institutes of Health).

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