Cooperative Agreement UG3HL182948
- Summary: CABANA-HF Clinical Trial Award Duke University's Office of Research Administration has been awarded $1,571,639 under a Cooperative Agreement from the National Heart, Lung, and Blood Institute (NHLBI) for the Cardiovascular Diseases Research program (CFDA 93.837), effective July 10, 2026, with completion scheduled for June 30, 2033. The award funds the CABANA-HF (Catheter Ablation Versus Antiarrhythmic and Heart Failure Drug Therapy in Preserved Ejection Fraction Heart Failure) trial,...
- Federal Grant Award Summary Brigham and Women's Hospital received an award of $855,585 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), with an award date of August 20, 2025, and a completion date of July 31, 2028. This Project Grant funds the development and adaptation of an antihypertensive self-titration intervention for routine implementation in U.S. primary care settings. The project addresses the clinical challenge...
- Federal Cooperative Agreement Summary Icahn School of Medicine at Mount Sinai received a $770,844 Cooperative Agreement from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) awarded on September 15, 2025. The award funds the ROMA:WOMEN trial, the first randomized controlled study exclusively enrolling women to compare outcomes of multiple arterial grafts (MAG) versus single arterial grafts (SAG) in coronary artery bypass...
- Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded $745,663 to the University of Utah under the Cardiovascular Diseases Research program (CFDA 93.837) for a project grant effective September 1, 2025, through June 30, 2029. The project, "Novel Roles for IRE1 in Regulating Cardiac Fibrosis," investigates mechanistic contributions of the unfolded protein response (UPR)—specifically the IRE1 (inositol-requiring enzyme 1) pathway—in regulating cardiac...
- Federal Grant Award Summary Vanderbilt University Medical Center received a $1.73 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded June 1, 2026, with completion targeted for February 29, 2028. The award funds therapeutic development of ENT-verticilide, a selective ryanodine receptor type 2 (RYR2) inhibitor, as a novel antiarrhythmic treatment for atrial fibrillation (AF). The research...
- Federal Grant Award Summary Baylor College of Medicine received a $673,598 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 15, 2025, with a completion date of June 30, 2029. The project, "Cardiomyocyte-Fibroblast Signaling in Atrial Fibrillation," delivers basic and translational research services investigating molecular mechanisms underlying atrial fibrillation (AF), a...
- Federal Grant Award Summary The University of Utah received a $183,600 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 19, 2025, with completion by August 31, 2027. The award funds research investigating metabolite transport modulation to mitigate myocardial ischemic-reperfusion (I/R) injury, a cardiac injury mechanism that occurs during standard heart attack treatment protocols...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded $246,000 to the University of California, San Francisco (UCSF) under the Cardiovascular Diseases Research program (CFDA 93.837) on July 6, 2026, with a completion date of June 30, 2028. This R21 resubmission leverages UCSF's existing Ventricular Tachycardia (VT) Database—a comprehensive, expertly annotated dataset encompassing 5,679 consecutive intensive care unit (ICU) patients with 572,574 hours...
- Federal Cooperative Agreement Summary Award Details: The National Heart, Lung, and Blood Institute (NHLBI) awarded The Ohio State University a Cooperative Agreement valued at $1,535,439 under the Cardiovascular Diseases Research program (CFDA 93.837) on September 15, 2025, with completion targeted for December 31, 2026. The award funds the WINDSURFER Trial (WIN Ratio Analysis to Determine a Strategy of Non-Invasive Support for Respiratory Failure in the Emergency Department), a multi-site...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Washington $2.81 million on September 24, 2025, under CFDA 93.837 (Cardiovascular Diseases Research) to conduct proteomic and genomic discovery research identifying molecular targets for atrial cardiopathy-related cardiovascular outcomes. The project, extending through June 30, 2029, employs proteomics and genomics methodologies across primary and secondary prevention populations to...
IHC Health Services Inc., doing business as Intermountain Healthcare, received a $1.29M cooperative agreement from the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), awarded July 10, 2026, with an ultimate completion date of June 30, 2027. The award funds Intermountain Healthcare's participation in the CABANA-HF (Catheter Ablation Versus Antiarrhythmic and Heart Failure Drug Therapy in Preserved Ejection Fraction Heart Failure) clinical trial, a multi-center, randomized controlled study designed to evaluate whether percutaneous left atrial catheter ablation combined with guideline-directed medical therapy provides superior outcomes compared to medical therapy alone for patients with heart failure with preserved ejection fraction and atrial fibrillation. As a clinical research site, Intermountain Healthcare delivers patient recruitment, protocol implementation, institutional review board coordination, clinical data collection, and electronic health record data extraction and harmonization services to support the trial's 5-year duration (3 years recruitment, 2 years follow-up) and enrollment of 1,552 patients across multiple centers. The trial's primary endpoints include cardiovascular mortality or worsening heart failure, with secondary endpoints encompassing all-cause mortality, quality of life assessments, and cost-effectiveness analyses. An independent clinical events committee will adjudicate primary and major secondary clinical events. Intermountain Healthcare's role aligns with its established footprint as a clinical research partner within multi-institutional consortia sponsored by the National Heart, Lung, and Blood Institute.Summary of CABANA-HF Cooperative Agreement Award
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.3m | 7/9/26 |