Cooperative Agreement UG3HL169564
- The National Heart Lung and Blood Institute (NHLBI), under the federal Cardiovascular Diseases Research program (CFDA 93.837), has awarded a $770,844 Cooperative Agreement to the Icahn School of Medicine at Mount Sinai (ISMMS) to conduct the "RANDOMIZED COMPARISON OF THE OUTCOMES OF SINGLE VS MULTIPLE ARTERIAL GRAFTS TRIAL IN WOMEN (ROMA:WOMEN)" study. This 5-year project, commencing on September 15, 2025, will enroll 2,000 women to determine the impact of multiple arterial grafts...
- The National Heart, Lung, and Blood Institute (NHLBI), through its Cardiovascular Diseases Research program (CFDA 93.837), awarded a $1,196,948 Cooperative Agreement to The Leland Stanford Junior University (Stanford University) on September 5, 2025. The award supports the "Women's Aneurysm Research: Repair Immediately or Routine Surveillance (WARRIORS) Trial", an international, randomized controlled trial designed to determine whether women aged 50+ with small (4.0-5.4 cm)...
- This federal Project Grant award of $174,389 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research by Dr. Nupoor Narula at Weill Medical College of Cornell University on the impact of aortic grafts on cardiovascular remodeling and outcomes in genetically triggered aortic aneurysms. The 5-year award, beginning September 5, 2025, will leverage advanced cardiac MRI techniques and rigorous genetic analyses to assess how the stiffness of...
- This federal Cooperative Agreement award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $318,167 to the University of Alabama at Birmingham (UAB) to conduct the Women's Aneurysm Research: Repair Immediately or Routine Surveillance (WARRIORS) Trial. This international, randomized controlled trial will compare early elective endovascular aortic repair (EVAR) to routine surveillance for women aged 50 and older...
- The federal Project Grant award titled "CARDIAC EFFECTS OF MINERALOCORTICOID RECEPTOR ANTAGONISM AFTER PREECLAMPSIA (CARDAMOM)" was awarded by the National Heart, Lung, and Blood Institute (CFDA #93.837 Cardiovascular Diseases Research) to The General Hospital Corporation, doing business as Massachusetts General Hospital, for $658,418.00. The award aims to conduct a randomized, double-blind clinical study investigating whether mineralocorticoid receptor blockade can promote favorable...
- This federal Project Grant award, provided by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), aims to apply state-of-the-art methods to evaluate the effectiveness of mechanical circulatory support (MCS) devices in treating acute myocardial infarction complicated by cardiogenic shock (AMI-CS). The $817,358 award, effective from August 19, 2025 to May 31, 2029, will support the following key activities: Appending individual patient...
- This federal Project Grant award of $2,981,544.00, awarded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), will fund a study to assess the impact of asymptomatic cytomegalovirus (CMV) infection on cardiovascular event risk in people with treated HIV infection. The study will leverage data from a prior clinical trial of the CMV-specific antiviral drug letermovir and a case-cohort study of over 1,900 ART-suppressed people with HIV to...
- This Project Grant award, valued at $733,439.00, was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to the Regents of the University of Michigan. The grant supports research to define the molecular triggers and consequences of CART signaling in aortic smooth muscle cells, and determine the role of sexually dimorphic signaling mechanisms in thoracic aortic aneurysm (TAA) pathogenesis. The research aims to advance the...
- The University of Cincinnati, through its Sponsored Research Services Division, was awarded a $156,276 project grant by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research on "Hematopoietic Cells and Chemokine Regulation in Abdominal Aortic Aneurysm Associated Thrombosis". The project, with a performance period from August 1, 2025 to June 30, 2027, aims to investigate the role of platelet activation and...
- This federal Project Grant award for $802,301, provided by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research by Weill Medical College of Cornell University to investigate the mechanisms that control the bone marrow "niche" environment and its role in expanding mutated blood stem cells that increase the risk of cardiovascular disease and cancer. The research aims to identify signaling pathways that can be targeted to prevent...
This Cooperative Agreement was awarded by the National Heart, Lung, and Blood Institute (CFDA# 93.837 Cardiovascular Diseases Research) to Weill Medical College of Cornell University to conduct the "Randomized Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women (ROMA:Women)" trial. The $1,048,249 award, which runs from September 2025 to August 2026, will evaluate whether using multiple arterial grafts instead of single arterial grafts leads to better outcomes in women undergoing coronary artery bypass grafting (CABG) surgery. The study aims to enroll 2,000 women to determine the impact on major adverse cardiac and cerebrovascular events, as well as quality of life measures. This trial leverages the existing infrastructure of the larger ROMA trial, which is examining the same intervention in the general CABG population.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.0m | 9/8/25 |