Cooperative Agreement UG3DE034134
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $248,750 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to the ADA Forsyth Institute, Inc. (doing business as The Forsyth Institute) located in Cambridge, Massachusetts. The grant will support research to determine the impact of cellular senescence on Sjögren's Syndrome-associated salivary gland dysfunction and salivary gland stem cell activity, with the goal of developing effective...
- This $429,000 Project Grant awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will fund research to evaluate the therapeutic potential of targeting phosphodiesterase-4 (PDE4) enzymes as a novel approach to alleviate symptoms and address the underlying causes of salivary gland dysfunction and xerostomia (dry mouth) associated with Sjögren's syndrome. The research will be conducted by the University of...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $468,875 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to the Oklahoma Medical Research Foundation (OMRF) for the project "Aging, Sex Bias, and CD8 T Cell Exhaustion in Salivary Gland Inflammation." This 2-year grant, with a period of performance from Sep 19, 2025 to Sep 18, 2027, will investigate the age- and sex-related immune mechanisms involved in the salivary gland...
- This $363,221 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research by a collaborative partnership between Henry Ford Health and Michigan State University Health Sciences. The research aims to investigate the molecular mechanism of MIR6891-5P-regulated X chromosome skewing in Sjögren's disease, explore strategies to reverse this skewing, and establish the clinical...
- This federal Project Grant award, totaling $643,574, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The award was granted to Texas A&M University System Health Science Center to conduct research on the therapeutic mechanisms of induced pluripotent stem cell-derived mesenchymal stem cell (iPSC-MSC) extracellular vesicles for treating dry mouth caused by Sjögren's syndrome or radiation...
- The National Institute of Dental and Craniofacial Research (NIDCR), through the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $406,496 Project Grant to Antixero to develop an extended-duration hyaluronic acid-based oral rinse to provide relief for cancer patients suffering from xerostomia (chronic dry mouth). This innovative solution aims to address the significant unmet need for long-lasting, non-toxic treatments for this debilitating condition, which often...
- This $432,209 Project Grant awarded by the Office of the Director of the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) supports the development of microphysiological systems (MPSs) to study Sjögren's disease (SJD), a systemic autoimmune disorder affecting the salivary glands. The goal is to create MPSs that incorporate collagen density and fibroblasts to better recapitulate the in vivo epithelial cell and lymphocyte phenotypes and transcriptomes...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), is supporting research to identify mechanisms that can specifically protect or regenerate salivary glands without benefiting cancer growth after radiation therapy. The $714,711 award to the Icahn School of Medicine at Mount Sinai will fund the development of a scalable gene targeting system to test over 2,600 genetic...
- The federal Project Grant award of $309,038, issued on August 8, 2025 by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports the development of a novel anti-infective therapy for treating periodontitis. The project aims to develop a first-in-class inhibitor of the "red complex" bacteria (P. gingivalis, T. forsythia, and T. denticola) that are considered the causative agents of periodontitis, a...
- This $249,000 federal Project Grant, awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to identify cell fate determination processes specific to salivary cell populations in order to advance regenerative therapies. The principal investigator at Rutgers, The State University of New Jersey will conduct studies to understand the normal developmental processes and transcriptional and...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $429,158 Cooperative Agreement grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to Rise Therapeutics LLC, a biotechnology company based in Rockville, Maryland. The goal of this project is to develop a novel, immunological-directed Lactococcus lactis probiotic-based therapeutic for the treatment of Sjögren's syndrome, a debilitating autoimmune disease affecting the salivary and lacrimal glands. The project aims to leverage the ability of a bacterial protein, Colonization Factor Antigen I (CFA/I), to stimulate regulatory T-cells and modulate the immune response, in order to provide a potential long-term management approach for Sjögren's syndrome. The award has an August 14, 2025 start date and an August 13, 2026 ultimate completion date.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $429.2k | 8/14/25 |