Cooperative Agreement UG1CA189860

This Project Grant award from the National Cancer Institute (NCI), under the Cancer Treatment Research federal grant program (CFDA 93.395), provides $113,202 to support research capacity building efforts by Dr. Elie Dib at the Michigan Cancer Research Consortium (MCRC). The key products and services to be delivered through this award include: Contributing to MCRC initiatives aimed at increasing the rate of clinical trials enrollment by minority and underserved populations. Launching safety...

The National Cancer Institute (NCI) awarded a $767,324 Cooperative Agreement (CFDA 93.396 - Cancer Biology Research) to the Van Andel Research Institute (VAI) in Grand Rapids, Michigan. The purpose of this 5-year award, effective April 1, 2025, is to investigate how dietary caloric restriction regulates anti-tumor immunity through its impact on CD8 T cell metabolism and fate in the tumor microenvironment. The research aims to determine the mechanisms by which caloric restriction boosts CD8 T...

The Centers for Disease Control and Prevention (CDC) awarded a $920,000 Cooperative Agreement under CFDA 93.376 "Multiple Approaches to Support Young Breast Cancer Survivors and Metastatic Breast Cancer Patients" to the Michigan Department of Health and Human Services (MDHHS). The award will provide comprehensive psychosocial and structural support services to improve quality of life for young breast cancer survivors and metastatic breast cancer patients, with a focus on addressing...

The Fred Hutchinson Cancer Center was awarded a $5,151,564 Project Grant by the National Cancer Institute (CFDA 93.397 Cancer Centers Support Grants) to establish a Translational Research Program in Colorectal Cancer Disparities. The program aims to improve risk-stratified screening and early detection of colorectal cancer, reduce racial and ethnic disparities in colorectal cancer mortality, and discover novel therapeutic targets across diverse populations. The program will conduct 4...

This $248,194 Cooperative Agreement award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) supports research to improve communication between radiation oncologists and radiologists for cancer treatment planning and surveillance. The project aims to address systemic barriers that limit collaboration between these providers, which could enhance radiotherapy target accuracy, reduce treatment toxicity, and improve the efficiency and accuracy of post-treatment...

This Project Grant award from the U.S. Department of Health and Human Services Office of Minority Health, under the Community Programs to Improve Minority Health (CFDA 93.137) program, provides $599,959 over 4 years to Wayne State University to address colorectal cancer (CRC) screening and drug overdose (DO) disparities in metro Detroit, Michigan. The key products and services to be delivered include: Partnering with 5 community clinics to implement quality improvement projects to increase CRC...

The National Cancer Institute (NCI) awarded a $3,998,962 Cooperative Agreement titled "Cancer Cause and Prevention Research" (CFDA 93.393) to Northwestern University to establish the "Advancing Cancer Control Equity Research Through Transformative Solutions in Patient Navigation (ACCERT PN) Center". The center will develop community-engaged interventions, measures, and methods focused on innovative multi-level patient navigation approaches and implementation science within...

This Project Grant award from the Department of Health and Human Services National Institutes of Health National Cancer Institute provides $582,100 to East Carolina University to support research on the role of mitochondrial complex I deficiency in colorectal cancer (CRC) tumor growth and progression. The research aims to elucidate how accumulated mitochondrial DNA mutations that disrupt complex I activity can paradoxically support CRC tumorigenesis, despite the general requirement for...

This Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) provides $356,732 to The Medical College of Wisconsin, Inc. to investigate the role of the CCR6 chemokine receptor and its ligand CCL20 in regulating the function of regulatory T cells (Tregs) within the pancreatic cancer tumor microenvironment. The objectives are to: 1) characterize the enhanced immunosuppressive capabilities of CCR6+ Tregs compared to CCR6- Tregs, 2) assess the effects of CCL20...

This Cooperative Agreement, awarded by the National Cancer Institute (NCI) under the 21st Century Cures Act - Beau Biden Cancer Moonshot federal grant program (CFDA 93.353), will fund the construction of a three-dimensional (3D) multimodal molecular atlas of colorectal cancer (CRC) across different ages of onset. The $1,063,411 award to Vanderbilt University will support spatial mapping of tumor progression from precancerous to cancerous states, utilizing cutting-edge technologies such as...