Cooperative Agreement U44NS130589
Award Date
4/15/23
Completion Date
3/31/26
Dollars Obligated
$1.5M
Federal Agency
National Institute of Neurological Disorders and Stroke
Federal Grant Program
93.853
Assistance Type
Cooperative Agreement
Place of Performance
Tucson, AZ 85719, USA
Similar Awards
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $423,500 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the Augusta University Research Institute, Inc. The objective is to develop and evaluate engineered exosomes carrying neuron-targeting peptides and a therapeutic protein (neuroglobin) for treating ischemic stroke. The research will: 1) characterize the engineered exosomes and assess their...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $299,982 to Unandup, LLC to evaluate the safety and efficacy of their novel magnetic infusion platform for accelerating stroke thrombolysis. The platform is designed to overcome limitations of current thrombolytic treatments by rapidly delivering the clot-dissolving drug alteplase to...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a 2-year, $423,500 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to Wayne State University in Detroit, MI. The objective of this high-risk, high-reward research project is to investigate the use of remotely administered hypothermia (RAH) to the spleen as a novel neuroprotective therapy for ischemic stroke. The research aims to determine if suppressing splenic...
This $490,049 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will fund research by Shearit LLC to demonstrate the efficacy of their Lamiflo drug in reducing ischemic penumbra and core volumes and improving neurological recovery in a rodent model of acute ischemic stroke. The research aims to show that intravenous administration of Lamiflo, a...
The federal Project Grant award R01NS138410, with a total funding amount of $1,223,140.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) grant program. The project aims to test a novel biopharmaceutical agent called Sanguinate that is designed to boost arterial collateralization and deliver oxygen to ischemic tissue in order to mitigate cerebral infarct...
This Project Grant award of $377,875.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award, effective December 23, 2024 through November 30, 2029, will support research to develop engineered extracellular vesicles (EVs) that can co-deliver mitochondria and the therapeutic protein HSP27 to protect the blood-brain barrier and...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $492,749 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the University of Pittsburgh to develop a novel magnetic resonance imaging (MRI) technique called Ratiometric Dual (RDUAL) pH-Weighted MRI. This technique aims to enhance the ability to detect tissue acidosis in the ischemic penumbra and core during acute ischemic stroke, in order to better identify...
This $1,199,991 Project Grant award from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program aims to develop novel technologies for real-time assessment of blood clot properties to improve stroke treatment. The key products and services under this grant include: Integration of a sub-millimeter Raman fiber probe into a catheter for intravascular, in-vivo measurement of clot chemical composition. Training of a convolutional neural network to...
This $666,530 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop an MRI-based technique to map the cerebral metabolic rate of oxygen consumption (CMRO2) in acute ischemic stroke patients. The objective is to create an accessible method to evaluate ischemic lesion viability, as CMRO2 is a better predictor of reversible...
This Project Grant award of $498,995.00 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports the development of a highly parallelized interferometric near-infrared spectroscopy (INIRS) technology for the real-time, non-invasive measurement of cerebral blood flow (CBF). The project, led by Neuralenz, Inc., aims to create an integrated platform...