Cooperative Agreement U44NS128489
- This $999,998 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports the development of Renerva LLC's Peripheral Nerve Matrix (PNM) technology. PNM is a tissue-based hydrogel derived from porcine nerve that aims to improve functional outcomes for patients with challenging peripheral nerve gap injuries. The Phase I project will optimize the PNM...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $296,151 to Insoma Bio, Inc. to investigate the use of their proprietary Fractomer biomaterial to improve outcomes after peripheral nerve repair. The project aims to demonstrate that Fractomer, an injectable polypeptide scaffold, can provide the necessary mechanical support and...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is funding research to develop a novel strategy for peripheral nerve repair. The University of California, San Diego (UCSD) is the primary awardee, receiving $572,114 to support this project from August 2025 through June 2030. The proposed approach involves gradually lengthening the...
- Renerva LLC, a for-profit manufacturer, is developing peripheral nerve matrix (PNM) technologies to facilitate functional recovery in animal models of direct muscle neurotization (DMN) through a $494,955 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853). The two-year project aims to 1) optimize the formulation of a clinical-grade PNM product to provide...
- This Project Grant awarded by the National Science Foundation (CFDA 47.041 - Engineering) to Cleveland State University (CSU) provides $500,000 in funding from January 1, 2025 to December 31, 2027 to develop bioprinted tissue scaffolds with Schwann cell density gradients and electrical conductivity for peripheral nerve regeneration. The goal is to understand how Schwann cell density gradients and electrical properties within the scaffolds can enhance the regeneration of injured peripheral...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $500,000 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to Renerva LLC, a for-profit biomedical company based in Pittsburgh, PA. The grant, titled "PNM-CAP: A Novel Nerve Cap to Prevent Painful Neuroma Formation in Peripheral Nerve Injuries and Amputations", will support the development of a biodegradable nerve capping device to prevent the formation of painful neuromas...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $6,522,833 Project Grant to The Leland Stanford Junior University to conduct a mechanistic randomized clinical trial investigating the central and peripheral nervous system mechanisms of pain relief induced by peripheral nerve stimulation (PNS) for the treatment of refractory chronic neuropathic pain. The 3-year study, funded under the NIH HEAL Initiative's CFDA 93.279 Drug Abuse and Addiction Research Programs, aims...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health, awarded a $3,242,520 Cooperative Agreement to the University of Pittsburgh on September 1, 2025 to develop a fully implanted spinal cord stimulation (SCS) system to restore sensation and relieve phantom limb pain (PLP) in people with lower-limb amputation. The project aims to quantify the safety and feasibility of the SCS system and explore changes in brain representations associated...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $274,976 to Ecate LLC aims to develop a novel intraspinal stimulator system to restore sensation and volitional motor control in spinal cord injury patients. The project will fabricate nanopatterned stimulating electrodes coupled with custom CMOS chips to deliver spatially selective electrical stimulation to the spinal cord. This closed-loop neural interface system is intended...
- The Department of Defense's Military Medical Research and Development program (CFDA 12.420) awarded a $1,999,336 project grant to The Trustees of the Stevens Institute of Technology on March 1, 2024. The grant will support research and development of "BIOACTIVE NERVE GRAFTS FOR PERIPHERAL NERVE REGENERATION" over a 4-year period ending February 29, 2028. As a sub-award under this project, the University of Connecticut Health Center (UCHC) will also conduct research related to this...
THE NEUROSPAN BRIDGE: A DEVICE FOR PERIPHERAL NERVE REPAIR - PERIPHERAL NERVE INJURY (PNI) OCCURS IN 3% OF ALL TRAUMA CASES AND 30% OF COMBAT INJURIES TO THE EXTREMITIES, RESULTING IN A LOSS OF FIVE MILLION WORKING DAYS EACH YEAR AND COSTS OF $150 BILLION ANNUALLY IN THE U.S. THE STANDARD OF CARE IN THE CLINIC IS A NERVE AUTOGRAFT FROM THE PATIENTS' LEG. THE NEUROSPAN BRIDGE IS A UNIQUE, BIOMIMETIC, MULTI-CHANNEL SCAFFOLD THAT MAINTAINS LINEARITY THROUGHOUT THE STRUCTURE, THUS ACCELERATING AND GUIDING REGENERATING AXONS PRECISELY TO THEIR TARGETS ON THE DISTAL END OF THE TRANSECTED NERVE. IT HAS BEEN EXTENSIVELY TESTED IN GAPS UP TO 3CM-LONG AND DEMONSTRATED SUPERIORITY TO EXISTING DEVICES IN A SHORT-GAP ANIMAL MODEL, AND SUPERIORITY TO NERVE AUTOGRAFT IN A LONG-GAP ANIMAL MODEL. THIS PROJECT WILL PUT IN PLACE A PROGRAM TO FINALIZE PRE-CLINICAL STUDIES, SUBMIT AN IDE APPLICATION TO THE FDA AND CARRY OUT A FEASIBILITY CLINICAL STUDY FOLLOWED BY 510(K) APPLICATION. THE PROPOSED PROJECT BRINGS TOGETHER EXPERTS IN PERIPHERAL NERVE INJURY, AXONAL REGENERATION, NEUROLOGY, NEUROSURGERY AND BIOENGINEERING TO DEVELOP A PRACTICAL, COST-EFFECTIVE, CONSISTENT, AND TRANSNATIONALLY RELEVANT MEDICAL DEVICE FOR THE TREATMENT OF PERIPHERAL NERVE INJURY.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $94.5k | 8/29/25 | ||
| Not listed | $0 | 8/22/25 | ||
| Not listed | $500.0k | 9/11/24 | ||
| Not listed | $1.0m | 9/5/24 | ||
| Not listed | $0 | 6/6/24 |