Cooperative Agreement U34AR064494

This Project Grant award, valued at $246,800, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award will support the development of the Musculoskeletal Adaptive Platform Trial (MAPT) over an 18-month planning period. The MAPT aims to enable the simultaneous comparison of multiple interventions for fracture treatment in patients aged 65 and older. Key...

This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) provides $279,354 to Northwestern University to conduct research on preventing bone loss and maintaining bone mass after spinal cord injury. The study will evaluate the use of the drug denosumab followed by zoledronic acid to prevent significant bone loss that commonly occurs in individuals with...

The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $783,176 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to Mayo Clinic to develop and validate a quantitative imaging methodology using photon-counting detector computed tomography (PCD-CT) for comprehensive assessment of bone quality in osteoporosis patients. The project aims to first develop and validate the PCD-CT imaging approach using...

The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded a $299,428 Project Grant to WNT Scientific LLC to develop an innovative medical device to treat nonunion fractures in older adults. The device is a biodegradable, controlled-release material designed to promote fracture healing by stimulating angiogenesis (blood vessel formation), which is impaired in elderly patients due to chronic inflammation. The awarded project aims to commercialize this...

This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $1,459,877 to the Magee-Womens Research Institute and Foundation to develop a bioinspired composite scaffold for the repair of pubovisceral muscle enthesis (PVME) injuries that commonly occur during vaginal childbirth and lead to pelvic organ prolapse. The research aims to define the...

This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $465,663 to optimize the bone surface targeting of therapeutic antibodies for the treatment of osteoporosis. The key objectives are to: 1) Optimize the pharmacokinetics and pharmacodynamics of an anti-sclerostin antibody in healthy and ovariectomy-induced osteoporosis animal models, and...

This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), provides $533,675 to the Trustees of Dartmouth College to conduct research on improving bone quality and regeneration in head and neck cancer patients after radiation therapy. The key objectives are to: Develop a combined 3D-printed mineral framework and cryogel scaffold to enhance bone formation and resist...

The Department of Defense's Military Medical Research and Development program (CFDA 12.420) awarded a $1,999,924 Project Grant to the Trustees of Indiana University to support a 3-year research project titled "EARLY IMMUNOLOGIC PRECISION TYPING AT-RISK FRACTURES TO PREDICT NONUNION". The project aims to characterize the temporal immune/inflammatory biomarker profile in patients with open tibial fractures and develop a predictive model to guide decision-making for musculoskeletal...

This federal Project Grant award of $765,546, awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to develop a novel non-invasive method for assessing bone turnover in patients with chronic kidney disease (CKD). The project aims to evaluate a "virtual bone biopsy" approach using time-lapse high-resolution peripheral quantitative computed...

This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), is developing the X-Visual, a sensor to track fracture healing in cannulated screws used for hip fracture fixation. The $299,999 award to Aravis Biotech LLC will cover the design, computational modeling, and initial testing of this innovative device that can non-invasively measure screw bending...