Diagnosing the unknown for care and advancing science (ducas)
Active Cooperative Agreement Awarded Last action
- Award ID
- U2CNS132415
- Recipient
-
President And Fellows Of Harvard College UEI JDLVAVGYJQ21 Part of Harvard College President & Fellows Of
- Awarding agency
-
National Institute of Neurological Disorders and Stroke
National Institutes of Health, Department of Health and Human Services
- Obligated
- $59,366,899
Award facts
- Assistance listing
- 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders
- Completion date 71% complete
- Place of performance
- Mission Hill, MA 02120, USA
Award details come from USAspending.gov.
Description
- Abstract
- In our current healthcare system, IT often takes years before patients with rare conditions and rare presentations of common conditions receive a diagnosis. In 2013, the national institutes of health supported the creation of the undiagnosed diseases network (UDN) to address the needs of these patients, to facilitate the diagnostic process for those with undiagnosed conditions and generate new knowledge about underlying mechanisms of disease. The UDN was successful in solving medical mysteries, shortening diagnostic odysseys, and contributing to biomedical research discovery. In order to serve more patients, the UDN process must be scaled and integrated into broader healthcare and research ecosystems. As the data management coordinating center (dmcc) for a network of diagnostic centers of excellence, harvard medical school will leverage experience in the UDN to create sustainable, nationally scaled infrastructure to support diagnosis, research, and care for those who are undiagnosed. This will be accomplished by bringing together experts in trans-institutional data sharing, data analysis, clinical care, bioinformatics, novel diagnostics, and translational research and creating three dmcc cores - administrative, data management, and clinical research support - to address unmet needs of the undiagnosed. The administrative core will unite the dmcc and support activities of all three cores. Together, the dmcc cores will accomplish four aims: 1) scale up UDN throughput by at least an order of magnitude to meet a pressing national need, 2) leverage partnerships for sustainable coordination of diagnostic processes to increase patient autonomy while advancing opportunities for investigative science, 3) maximize data mobility, interpretability, and shareability, and 4) provide analytic service and data stewardship through the data management core and clinical research support cores led by experts in genomics and AI teaming with clinicians and researchers.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $2,700,000 | |
| Amendment | $1,000,000 | |
| Amendment | $1,000,000 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $2,457,018 | |
| Amendment | $2,457,018 | |
| Amendment | -$75,000 | |
| Amendment | -$67,500 | |
| Amendment | $75,000 | |
| Amendment | $500,000 | |
| Amendment | $500,000 | |
| Amendment | $75,000 | |
| Amendment | $116,258 | |
| Amendment | $150,000 | |
| Amendment | $150,000 | |
| Amendment | $150,000 | |
| Amendment | $150,000 | |
| Amendment | $32,479 | |
| Amendment | $176,960 | |
| Amendment | $176,960 | |
| Amendment | $500,000 | |
| Amendment | $500,000 | |
| Amendment | $500,000 | |
| Amendment | -$1,099,240 | |
| Amendment | -$25,000 | |
| Amendment | -$25,000 | |
| Amendment | $25,000 | |
| Amendment | $4,173,694 | |
| Amendment | $4,173,694 | |
| Amendment | $4,173,694 | |
| Amendment | $4,173,694 | |
| Amendment | $10,920 | |
| Amendment | -$10,920 | |
| Amendment | $10,920 | |
| Amendment | -$10,920 | |
| Amendment | $10,920 | |
| Amendment | -$175,000 | |
| Amendment | $50,000 | |
| Amendment | -$175,000 | |
| Amendment | $50,000 | |
| Amendment | $50,000 | |
| Amendment | $15,000 | |
| Amendment | $15,000 | |
| Amendment | $50,000 | |
| Amendment | $50,000 | |
| Amendment | $7,500 | |
| Amendment | $1,092 | |
| Amendment | $9,828 |
Show 40 more
Latest 50 listed here. See the rest on GovTribe.
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Frameshift Labs, Inc. | $99,734 | |
| Undiagnosed Diseases Network Foundation | $150,000 | |
| Baylor College Of Medicine | $940,458 | |
| The Washington University | $230,002 | |
| University Of Oregon | $210,000 | |
| Baylor College Of Medicine | $700,000 | |
| Harvard Pilgrim Health Care, Inc. | $21,000 | |
| Baylor College Of Medicine | $1,090,400 | |
| Baylor College Of Medicine | $3,051,162 | |
| The Washington University | $188,792 | |
| University Of Oregon | $31,273 | |
| Harvard Pilgrim Health Care, Inc. | $101,005 | |
| The Morehouse School Of Medicine, Inc. | $745,967 | |
| Commonspirit Health Research Institute | $36,132 | |
| Baylor College Of Medicine | $836,342 | |
| University Of Oregon | $63,000 | |
| Baylor College Of Medicine | $248,720 | |
| The Washington University | $2,934,056 | |
| The Leland Stanford Junior University | $953,602 | |
| University Of Utah | $869,351 | |
| The Morehouse School Of Medicine, Inc. | $1,102,934 | |
| University Of Alabama At Birmingham | $1,140,302 |
Show all 22
Quick answers
Who received award U2CNS132415?
U2CNS132415 was awarded to President And Fellows Of Harvard College by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on April 19, 2023.
How much is award U2CNS132415 worth?
$59,366,899 has been obligated on U2CNS132415.
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